Pisha E - Search Results

1

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis.

Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH, Kinghorn AD, Brown DM, et al. Pisha E, et al. Nat Med. 1995 Oct;1(10):1046-51. doi: 10.1038/nm1095-1046. Nat Med. 1995. PMID: 7489361

2

Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.

Chang LC, Bhat KP, Pisha E, Kennelly EJ, Fong HH, Pezzuto JM, Kinghorn AD. Chang LC, et al. Among authors: pisha e. J Nat Prod. 1998 Oct;61(10):1257-62. doi: 10.1021/np980162x. J Nat Prod. 1998. PMID: 9784163

3

Synthesis of betulinic acid derivatives with activity against human melanoma.

Kim DS, Pezzuto JM, Pisha E. Kim DS, et al. Among authors: pisha e. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1707-12. doi: 10.1016/s0960-894x(98)00295-9. Bioorg Med Chem Lett. 1998. PMID: 9873420

4

The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.

Bolton JL, Pisha E, Shen L, Krol ES, Iverson SL, Huang Z, van Breemen RB, Pezzuto JM. Bolton JL, et al. Among authors: pisha e. Chem Biol Interact. 1997 Sep 12;106(2):133-48. doi: 10.1016/s0009-2797(97)00066-5. Chem Biol Interact. 1997. PMID: 9366899

5

A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.

Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL. Chen Y, et al. Among authors: pisha e. Chem Res Toxicol. 2000 May;13(5):342-50. doi: 10.1021/tx990186j. Chem Res Toxicol. 2000. PMID: 10813650

6

Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.

Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, van Breemen RB, Bolton JL. Shen L, et al. Among authors: pisha e. Carcinogenesis. 1997 May;18(5):1093-101. doi: 10.1093/carcin/18.5.1093. Carcinogenesis. 1997. PMID: 9163701

7

Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha.

Liu X, Yao J, Pisha E, Yang Y, Hua Y, van Breemen RB, Bolton JL. Liu X, et al. Among authors: pisha e. Chem Res Toxicol. 2002 Apr;15(4):512-9. doi: 10.1021/tx0101649. Chem Res Toxicol. 2002. PMID: 11952337

8

Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.

Liu X, Pisha E, Tonetti DA, Yao D, Li Y, Yao J, Burdette JE, Bolton JL. Liu X, et al. Among authors: pisha e. Chem Res Toxicol. 2003 Jul;16(7):832-7. doi: 10.1021/tx030004s. Chem Res Toxicol. 2003. PMID: 12870885

9

Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1.

Yao J, Chang M, Li Y, Pisha E, Liu X, Yao D, Elguindi EC, Blond SY, Bolton JL. Yao J, et al. Among authors: pisha e. Chem Res Toxicol. 2002 Jul;15(7):935-42. doi: 10.1021/tx020018i. Chem Res Toxicol. 2002. PMID: 12119004

10

The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.

Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL. Zhang F, et al. Among authors: pisha e. Chem Res Toxicol. 1999 Feb;12(2):204-13. doi: 10.1021/tx980217v. Chem Res Toxicol. 1999. PMID: 10027800

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