Nar H - Search Results

1

Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans. Phosphorylation is a requirement for in vivo activity.

Oppliger T, Thöny B, Nar H, Bürgisser D, Huber R, Heizmann CW, Blau N. Oppliger T, et al. Among authors: nar h. J Biol Chem. 1995 Dec 8;270(49):29498-506. doi: 10.1074/jbc.270.49.29498. J Biol Chem. 1995. PMID: 7493990 Free article.

2

6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding.

Bürgisser DM, Thöny B, Redweik U, Hess D, Heizmann CW, Huber R, Nar H. Bürgisser DM, et al. Among authors: nar h. J Mol Biol. 1995 Oct 20;253(2):358-69. doi: 10.1006/jmbi.1995.0558. J Mol Biol. 1995. PMID: 7563095

3

Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis.

Nar H, Huber R, Heizmann CW, Thöny B, Bürgisser D. Nar H, et al. EMBO J. 1994 Mar 15;13(6):1255-62. doi: 10.1002/j.1460-2075.1994.tb06377.x. EMBO J. 1994. PMID: 8137809 Free PMC article.

4

Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.

Ploom T, Thöny B, Yim J, Lee S, Nar H, Leimbacher W, Richardson J, Huber R, Auerbach G. Ploom T, et al. Among authors: nar h. J Mol Biol. 1999 Feb 26;286(3):851-60. doi: 10.1006/jmbi.1998.2511. J Mol Biol. 1999. PMID: 10024455

5

Atomic structure of GTP cyclohydrolase I.

Nar H, Huber R, Meining W, Schmid C, Weinkauf S, Bacher A. Nar H, et al. Structure. 1995 May 15;3(5):459-66. doi: 10.1016/s0969-2126(01)00179-4. Structure. 1995. PMID: 7663943 Free article.

6

Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate.

Bracher A, Fischer M, Eisenreich W, Ritz H, Schramek N, Boyle P, Gentili P, Huber R, Nar H, Auerbach G, Bacher A. Bracher A, et al. Among authors: nar h. J Biol Chem. 1999 Jun 11;274(24):16727-35. doi: 10.1074/jbc.274.24.16727. J Biol Chem. 1999. PMID: 10358012 Free article.

7

The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase.

Auerbach G, Nar H. Auerbach G, et al. Among authors: nar h. Biol Chem. 1997 Mar-Apr;378(3-4):185-92. Biol Chem. 1997. PMID: 9165069 Review.

8

X-ray crystal structure of the two site-specific mutants Ile7Ser and Phe110Ser of azurin from Pseudomonas aeruginosa.

Hammann C, Messerschmidt A, Huber R, Nar H, Gilardi G, Canters GW. Hammann C, et al. Among authors: nar h. J Mol Biol. 1996 Jan 26;255(3):362-6. doi: 10.1006/jmbi.1996.0029. J Mol Biol. 1996. PMID: 8568881

9

Locating a local symmetry axis from patterson map cross vectors: application to crystal data from GroEl, GTP cyclohydrolase I and the proteosome.

Stubbs MT, Nar H, Löwe J, Huber R, Ladenstein R, Spangfort MD, Svensson LA. Stubbs MT, et al. Among authors: nar h. Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):447-52. doi: 10.1107/S0907444995014144. Acta Crystallogr D Biol Crystallogr. 1996. PMID: 15299665

10

Zinc plays a key role in human and bacterial GTP cyclohydrolase I.

Auerbach G, Herrmann A, Bracher A, Bader G, Gutlich M, Fischer M, Neukamm M, Garrido-Franco M, Richardson J, Nar H, Huber R, Bacher A. Auerbach G, et al. Among authors: nar h. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13567-72. doi: 10.1073/pnas.240463497. Proc Natl Acad Sci U S A. 2000. PMID: 11087827 Free PMC article.

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