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Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.
Rice WG, Supko JG, Malspeis L, Buckheit RW Jr, Clanton D, Bu M, Graham L, Schaeffer CA, Turpin JA, Domagala J, Gogliotti R, Bader JP, Halliday SM, Coren L, Sowder RC 2nd, Arthur LO, Henderson LE. Rice WG, et al. Among authors: domagala j. Science. 1995 Nov 17;270(5239):1194-7. doi: 10.1126/science.270.5239.1194. Science. 1995. PMID: 7502043
The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities.
Tummino PJ, Harvey PJ, McQuade T, Domagala J, Gogliotti R, Sanchez J, Song Y, Hupe D. Tummino PJ, et al. Among authors: domagala j. Antimicrob Agents Chemother. 1997 Feb;41(2):394-400. doi: 10.1128/AAC.41.2.394. Antimicrob Agents Chemother. 1997. PMID: 9021197 Free PMC article.
The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity.
Tummino PJ, Scholten JD, Harvey PJ, Holler TP, Maloney L, Gogliotti R, Domagala J, Hupe D. Tummino PJ, et al. Among authors: domagala j. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):969-73. doi: 10.1073/pnas.93.3.969. Proc Natl Acad Sci U S A. 1996. PMID: 8577770 Free PMC article.
Several disulfide benzamides have been shown to possess wide-spectrum antiretroviral activity in cell culture at low micromolar to submicromolar concentrations, inhibiting human immunodeficiency virus (HIV) type 1 (HIV-1) clinical and drug-resistant strains along with HIV-2 and s …
Several disulfide benzamides have been shown to possess wide-spectrum antiretroviral activity in cell culture at low micromolar to submicrom …
4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.
Hagen SE, Domagala J, Gajda C, Lovdahl M, Tait BD, Wise E, Holler T, Hupe D, Nouhan C, Urumov A, Zeikus G, Zeikus E, Lunney EA, Pavlovsky A, Gracheck SJ, Saunders J, VanderRoest S, Brodfuehrer J. Hagen SE, et al. Among authors: domagala j. J Med Chem. 2001 Jul 5;44(14):2319-32. doi: 10.1021/jm0003844. J Med Chem. 2001. PMID: 11428926
138 results