Jenkinson S - Search Results

1

Structural and functional similarities between the promoters for mouse tenascin and chicken cytotactin.

Copertino DW, Jenkinson S, Jones FS, Edelman GM. Copertino DW, et al. Among authors: jenkinson s. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2131-5. doi: 10.1073/pnas.92.6.2131. Proc Natl Acad Sci U S A. 1995. PMID: 7534412 Free PMC article.

2

Silencer elements modulate the expression of the gene for the neuron-glia cell adhesion molecule, Ng-CAM.

Kallunki P, Jenkinson S, Edelman GM, Jones FS. Kallunki P, et al. Among authors: jenkinson s. J Biol Chem. 1995 Sep 8;270(36):21291-8. doi: 10.1074/jbc.270.36.21291. J Biol Chem. 1995. PMID: 7545667 Free article.

3

Ligand biological activity predicted by cleaning positive and negative chemical correlations.

Lee AA, Yang Q, Bassyouni A, Butler CR, Hou X, Jenkinson S, Price DA. Lee AA, et al. Among authors: jenkinson s. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3373-3378. doi: 10.1073/pnas.1810847116. Epub 2019 Feb 11. Proc Natl Acad Sci U S A. 2019. PMID: 30808733 Free PMC article.

4

[No title available]

[No authors listed] [No authors listed] PMID: 31962905

5

Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints.

Jenkinson S, Goody SMG, Bassyouni A, Jones R, Otto-Bruc A, Duquennoy S, DaSilva JK, Butler P, Mead A. Jenkinson S, et al. J Pharmacol Toxicol Methods. 2020 Jul-Aug;104:106899. doi: 10.1016/j.vascn.2020.106899. Epub 2020 Jul 21. J Pharmacol Toxicol Methods. 2020. PMID: 32702414

6

L-type calcium channel antagonism - Translation from in vitro to in vivo.

Fermini B, Ramirez DS, Sun S, Bassyouni A, Hemkens M, Wisialowski T, Jenkinson S. Fermini B, et al. Among authors: jenkinson s. J Pharmacol Toxicol Methods. 2017 Mar-Apr;84:86-92. doi: 10.1016/j.vascn.2016.11.002. Epub 2016 Nov 15. J Pharmacol Toxicol Methods. 2017. PMID: 27856310

7

Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation.

Jenkinson S, Bassyouni A, Cordes J, Fermini B, Guo D, Potter DM, Ramirez DS, Steidl-Nichols J, Sun S, Wisialowski T. Jenkinson S, et al. J Pharmacol Toxicol Methods. 2018 Jan-Feb;89:9-18. doi: 10.1016/j.vascn.2017.10.002. Epub 2017 Oct 16. J Pharmacol Toxicol Methods. 2018. PMID: 29042254

8

Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters.

Kilfoil P, Feng SL, Bassyouni A, Lee T, Leishman D, Li D, MacEwan DJ, Sharma P, Watt ED, Jenkinson S. Kilfoil P, et al. Among authors: jenkinson s. Eur J Pharmacol. 2021 Dec 5;912:174584. doi: 10.1016/j.ejphar.2021.174584. Epub 2021 Oct 19. Eur J Pharmacol. 2021. PMID: 34678241 Free article.

9

Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H₁ Receptor Inverse Agonist.

Lall MS, Bassyouni A, Bradow J, Brown M, Bundesmann M, Chen J, Ciszewski G, Hagen AE, Hyek D, Jenkinson S, Liu B, Obach RS, Pan S, Reilly U, Sach N, Smaltz DJ, Spracklin DK, Starr J, Wagenaar M, Walker GS. Lall MS, et al. Among authors: jenkinson s. J Med Chem. 2020 Jul 9;63(13):7268-7292. doi: 10.1021/acs.jmedchem.0c00483. Epub 2020 Jun 8. J Med Chem. 2020. PMID: 32462865

10

Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.

Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S, Kauffman GW, Kenakin TP, Lazzaro JT, Lotarski SM, Mao Y, Nason DM, Northcott C, Nottebaum L, O'Neil SV, Pettersen B, Popiolek M, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Zhang L, Grimwood S. Davoren JE, et al. Among authors: jenkinson s. J Med Chem. 2016 Jul 14;59(13):6313-28. doi: 10.1021/acs.jmedchem.6b00544. Epub 2016 Jul 1. J Med Chem. 2016. PMID: 27275946

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