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Comprehensive pharmacokinetics of a humanized antibody and analysis of residual anti-idiotypic responses.
Immunology. 1995 Aug;85(4):668-74.
Immunology. 1995.
PMID: 7558164
Free PMC article.
The engineered human anti-tumor necrosis factor-alpha antibody CDP571 inhibits inflammatory pathways but not T cell activation in patients with rheumatoid arthritis.
Choy EH, Rankin EC, Kassimos D, Vetterlein O, Garyfallos A, Ravirajan CT, Sopwith M, Eastell R, Kingsley GH, Isenberg DA, Panayi GS.
Choy EH, et al. Among authors: vetterlein o.
J Rheumatol. 1999 Nov;26(11):2310-7.
J Rheumatol. 1999.
PMID: 10555883
Clinical Trial.
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The S228P mutation prevents in vivo and in vitro IgG4 Fab-arm exchange as demonstrated using a combination of novel quantitative immunoassays and physiological matrix preparation.
Silva JP, Vetterlein O, Jose J, Peters S, Kirby H.
Silva JP, et al. Among authors: vetterlein o.
J Biol Chem. 2015 Feb 27;290(9):5462-9. doi: 10.1074/jbc.M114.600973. Epub 2015 Jan 7.
J Biol Chem. 2015.
PMID: 25568323
Free PMC article.
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F(ab')2 molecules made from Escherichia coli produced Fab' with hinge sequences conferring increased serum survival in an animal model.
Humphreys DP, Vetterlein OM, Chapman AP, King DJ, Antoniw P, Suitters AJ, Reeks DG, Parton TA, King LM, Smith BJ, Lang V, Stephens PE.
Humphreys DP, et al. Among authors: vetterlein om.
J Immunol Methods. 1998 Aug 1;217(1-2):1-10. doi: 10.1016/s0022-1759(98)00061-1.
J Immunol Methods. 1998.
PMID: 9776570
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