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Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.
MacKenzie SJ, Yarwood SJ, Peden AH, Bolger GB, Vernon RG, Houslay MD. MacKenzie SJ, et al. Among authors: bolger gb. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3549-54. doi: 10.1073/pnas.95.7.3549. Proc Natl Acad Sci U S A. 1998. PMID: 9520403 Free PMC article.
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
Huston E, Pooley L, Julien P, Scotland G, McPhee I, Sullivan M, Bolger G, Houslay MD. Huston E, et al. Among authors: bolger g. J Biol Chem. 1996 Dec 6;271(49):31334-44. doi: 10.1074/jbc.271.49.31334. J Biol Chem. 1996. PMID: 8940140 Free article.
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Houslay MD, Scotland G, Erdogan S, Huston E, Mackenzie S, McCallum JF, McPhee I, Pooley L, Rena G, Ross A, Beard M, Peder A, Begg F, Wilkinson I, Yarwood S, Ackerman C, Houslay ES, Hoffman R, Engels P, Sullivan M, Bolger G. Houslay MD, et al. Among authors: bolger g. Biochem Soc Trans. 1997 May;25(2):374-81. doi: 10.1042/bst0250374. Biochem Soc Trans. 1997. PMID: 9191121 Review. No abstract available.
183 results