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Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.
Houslay MD, Scotland G, Pooley L, Spence S, Wilkinson I, McCallum F, Julien P, Rena NG, Michie AM, Erdogan S, et al. Houslay MD, et al. Among authors: pooley l. Biochem Soc Trans. 1995 May;23(2):393-8. doi: 10.1042/bst0230393. Biochem Soc Trans. 1995. PMID: 7672427 Review. No abstract available.
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
Huston E, Pooley L, Julien P, Scotland G, McPhee I, Sullivan M, Bolger G, Houslay MD. Huston E, et al. Among authors: pooley l. J Biol Chem. 1996 Dec 6;271(49):31334-44. doi: 10.1074/jbc.271.49.31334. J Biol Chem. 1996. PMID: 8940140 Free article.
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Houslay MD, Scotland G, Erdogan S, Huston E, Mackenzie S, McCallum JF, McPhee I, Pooley L, Rena G, Ross A, Beard M, Peder A, Begg F, Wilkinson I, Yarwood S, Ackerman C, Houslay ES, Hoffman R, Engels P, Sullivan M, Bolger G. Houslay MD, et al. Among authors: pooley l. Biochem Soc Trans. 1997 May;25(2):374-81. doi: 10.1042/bst0250374. Biochem Soc Trans. 1997. PMID: 9191121 Review. No abstract available.
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