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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.
Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, Pienta KJ, Ling X, Kang S, Guo M, Sun Y, Yang D, Wang S. Shangary S, et al. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8. doi: 10.1073/pnas.0708917105. Epub 2008 Mar 3. Proc Natl Acad Sci U S A. 2008. PMID: 18316739 Free PMC article.
A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.
Verhaegen M, Bauer JA, Martín de la Vega C, Wang G, Wolter KG, Brenner JC, Nikolovska-Coleska Z, Bengtson A, Nair R, Elder JT, Van Brocklin M, Carey TE, Bradford CR, Wang S, Soengas MS. Verhaegen M, et al. Cancer Res. 2006 Dec 1;66(23):11348-59. doi: 10.1158/0008-5472.CAN-06-1748. Cancer Res. 2006. PMID: 17145881
586 results