Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.
Schumacher R, Soos MA, Schlessinger J, Brandenburg D, Siddle K, Ullrich A.
Schumacher R, et al. Among authors: brandenburg d.
J Biol Chem. 1993 Jan 15;268(2):1087-94.
J Biol Chem. 1993.
PMID: 7678247
Free article.
In addition, both the IGF-1R/IR C3' chimera and another chimera (C13') displayed high affinity binding properties for IGF-1, which suggests distinct locations for major insulin and IGF-1 binding determinants in their respective receptors, in agreement with our previous findings ( …
In addition, both the IGF-1R/IR C3' chimera and another chimera (C13') displayed high affinity binding properties for IGF-1, which suggests …