Varney MD - Search Results

1

Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.

Varney MD, Palmer CL, Deal JG, Webber S, Welsh KM, Bartlett CA, Morse CA, Smith WW, Janson CA. Varney MD, et al. J Med Chem. 1995 May 26;38(11):1892-903. doi: 10.1021/jm00011a009. J Med Chem. 1995. PMID: 7783121

2

Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase.

Varney MD, Marzoni GP, Palmer CL, Deal JG, Webber S, Welsh KM, Bacquet RJ, Bartlett CA, Morse CA, Booth CL, et al. Varney MD, et al. J Med Chem. 1992 Feb 21;35(4):663-76. doi: 10.1021/jm00082a006. J Med Chem. 1992. PMID: 1542093

3

Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease.

Varney MD, Appelt K, Kalish V, Reddy MR, Tatlock J, Palmer CL, Romines WH, Wu BW, Musick L. Varney MD, et al. J Med Chem. 1994 Jul 22;37(15):2274-84. doi: 10.1021/jm00041a005. J Med Chem. 1994. PMID: 8057276

4

Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.

Jones TR, Varney MD, Webber SE, Lewis KK, Marzoni GP, Palmer CL, Kathardekar V, Welsh KM, Webber S, Matthews DA, Appelt K, Smith WW, Janson CA, Villafranca JE, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Moomaw EW, Bartlett CA, Morse CA. Jones TR, et al. Among authors: varney md. J Med Chem. 1996 Feb 16;39(4):904-17. doi: 10.1021/jm9502652. J Med Chem. 1996. PMID: 8632414

5

Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.

Jones TR, Webber SE, Varney MD, Reddy MR, Lewis KK, Kathardekar V, Mazdiyasni H, Deal J, Nguyen D, Welsh KM, Webber S, Johnston A, Matthews DA, Smith WW, Janson CA, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Bartlett CA, Morse CA. Jones TR, et al. Among authors: varney md. J Med Chem. 1997 Feb 28;40(5):677-83. doi: 10.1021/jm960613f. J Med Chem. 1997. PMID: 9057854

6

Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.

Varney MD, Palmer CL, Romines WH 3rd, Boritzki T, Margosiak SA, Almassy R, Janson CA, Bartlett C, Howland EJ, Ferre R. Varney MD, et al. J Med Chem. 1997 Aug 1;40(16):2502-24. doi: 10.1021/jm9607459. J Med Chem. 1997. PMID: 9258357

7

Calculation of relative differences in the binding free energies of HIV1 protease inhibitors: a thermodynamic cycle perturbation approach.

Reddy MR, Varney MD, Kalish V, Viswanadhan VN, Appelt K. Reddy MR, et al. Among authors: varney md. J Med Chem. 1994 Apr 15;37(8):1145-52. doi: 10.1021/jm00034a012. J Med Chem. 1994. PMID: 8164256

8

Application of the three-dimensional structures of protein target molecules in structure-based drug design.

Greer J, Erickson JW, Baldwin JJ, Varney MD. Greer J, et al. Among authors: varney md. J Med Chem. 1994 Apr 15;37(8):1035-54. doi: 10.1021/jm00034a001. J Med Chem. 1994. PMID: 8164249 Review. No abstract available.

9

An approach to rapid estimation of relative binding affinities of enzyme inhibitors: application to peptidomimetic inhibitors of the human immunodeficiency virus type 1 protease.

Viswanadhan VN, Reddy MR, Wlodawer A, Varney MD, Weinstein JN. Viswanadhan VN, et al. Among authors: varney md. J Med Chem. 1996 Feb 2;39(3):705-12. doi: 10.1021/jm940778t. J Med Chem. 1996. PMID: 8576913

10

Sterility test incubation issue.

Wilson JD, Varney M. Wilson JD, et al. PDA J Pharm Sci Technol. 1995 Jul-Aug;49(4):157-9. PDA J Pharm Sci Technol. 1995. PMID: 7552233

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