Lee HH - Search Results

1

Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.

Hay MP, Lee HH, Wilson WR, Roberts PB, Denny WA. Hay MP, et al. Among authors: lee hh. J Med Chem. 1995 May 26;38(11):1928-41. doi: 10.1021/jm00011a013. J Med Chem. 1995. PMID: 7783125

2

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.

Hay MP, Hicks KO, Pchalek K, Lee HH, Blaser A, Pruijn FB, Anderson RF, Shinde SS, Wilson WR, Denny WA. Hay MP, et al. Among authors: lee hh. J Med Chem. 2008 Nov 13;51(21):6853-65. doi: 10.1021/jm800967h. Epub 2008 Oct 11. J Med Chem. 2008. PMID: 18847185 Free PMC article.

3

Potential antitumor agents. 64. Synthesis and antitumor evaluation of dibenzo[1,4]dioxin-1-carboxamides: a new class of weakly binding DNA-intercalating agents.

Lee HH, Palmer BD, Boyd M, Baguley BC, Denny WA. Lee HH, et al. J Med Chem. 1992 Jan 24;35(2):258-66. doi: 10.1021/jm00080a009. J Med Chem. 1992. PMID: 1310119

4

DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1,2-diaminoethane)dichloroplatinum(II).

Lee HH, Palmer BD, Baguley BC, Chin M, McFadyen WD, Wickham G, Thorsbourne-Palmer D, Wakelin LP, Denny WA. Lee HH, et al. J Med Chem. 1992 Aug 7;35(16):2983-7. doi: 10.1021/jm00094a008. J Med Chem. 1992. PMID: 1501223

5

DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine.

Palmer BD, Lee HH, Johnson P, Baguley BC, Wickham G, Wakelin LP, McFadyen WD, Denny WA. Palmer BD, et al. Among authors: lee hh. J Med Chem. 1990 Nov;33(11):3008-14. doi: 10.1021/jm00173a015. J Med Chem. 1990. PMID: 2231598

6

Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide.

Lee HH, Wilson WR, Ferry DM, van Zijl P, Pullen SM, Denny WA. Lee HH, et al. J Med Chem. 1996 Jun 21;39(13):2508-17. doi: 10.1021/jm9600104. J Med Chem. 1996. PMID: 8691448

7

Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard.

Lee HH, Palmer BD, Wilson WR, Denny WA. Lee HH, et al. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1741-4. doi: 10.1016/s0960-894x(98)00305-9. Bioorg Med Chem Lett. 1998. PMID: 9873426

8

Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.

Lee HH, Wilson WR, Denny WA. Lee HH, et al. Anticancer Drug Des. 1999 Dec;14(6):487-97. Anticancer Drug Des. 1999. PMID: 10834270

9

Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.

Tercel M, Lee AE, Hogg A, Anderson RF, Lee HH, Siim BG, Denny WA, Wilson WR. Tercel M, et al. Among authors: lee ae, lee hh. J Med Chem. 2001 Oct 11;44(21):3511-22. doi: 10.1021/jm010202l. J Med Chem. 2001. PMID: 11585455

10

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.

Palmer BD, Thompson AM, Booth RJ, Dobrusin EM, Kraker AJ, Lee HH, Lunney EA, Mitchell LH, Ortwine DF, Smaill JB, Swan LM, Denny WA. Palmer BD, et al. Among authors: lee hh. J Med Chem. 2006 Aug 10;49(16):4896-911. doi: 10.1021/jm0512591. J Med Chem. 2006. PMID: 16884302

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