Hamel E - Search Results

1

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

Cushman M, He HM, Katzenellenbogen JA, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1995 Jun 9;38(12):2041-9. doi: 10.1021/jm00012a003. J Med Chem. 1995. PMID: 7783135

2

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

Getahun Z, Jurd L, Chu PS, Lin CM, Hamel E. Getahun Z, et al. Among authors: hamel e. J Med Chem. 1992 Mar 20;35(6):1058-67. doi: 10.1021/jm00084a011. J Med Chem. 1992. PMID: 1552500

3

Modulation of tubulin-nucleotide interactions by metal ions: comparison of beryllium with magnesium and initial studies with other cations.

Hamel E, Lin CM, Kenney S, Skehan P, Vaughns J. Hamel E, et al. Arch Biochem Biophys. 1992 Jun;295(2):327-39. doi: 10.1016/0003-9861(92)90525-2. Arch Biochem Biophys. 1992. PMID: 1586162

With microtubule-associated proteins (MAPs) BeSO4 and MgSO4 stimulated tubulin polymerization as compared to a reaction mixture without exogenously added metal ion, while beryllium fluoride had no effect (E. Hamel et al., 1991, Arch. Biochem. Biophys. 286, 57-69). E …

With microtubule-associated proteins (MAPs) BeSO4 and MgSO4 stimulated tubulin polymerization as compared to a reaction mixture without exog …

4

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1992 Jun 12;35(12):2293-306. doi: 10.1021/jm00090a021. J Med Chem. 1992. PMID: 1613753

5

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.

Paull KD, Lin CM, Malspeis L, Hamel E. Paull KD, et al. Among authors: hamel e. Cancer Res. 1992 Jul 15;52(14):3892-900. Cancer Res. 1992. PMID: 1617665

6

Highly variable effects of beryllium and beryllium fluoride on tubulin polymerization under different reaction conditions: comparison of assembly reactions dependent on microtubule-associated proteins, glycerol, dimethyl sulfoxide, and glutamate.

Hamel E, Lin CM, Kenney S, Skehan P. Hamel E, et al. Arch Biochem Biophys. 1991 Apr;286(1):57-69. doi: 10.1016/0003-9861(91)90008-7. Arch Biochem Biophys. 1991. PMID: 1680309

7

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1991 Aug;34(8):2579-88. doi: 10.1021/jm00112a036. J Med Chem. 1991. PMID: 1875350

8

Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)-one.

Lin CM, Kang GJ, Roach MC, Jiang JB, Hesson DP, Luduena RF, Hamel E. Lin CM, et al. Among authors: hamel e. Mol Pharmacol. 1991 Nov;40(5):827-32. Mol Pharmacol. 1991. PMID: 1944246

9

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.

Jiang JB, Hesson DP, Dusak BA, Dexter DL, Kang GJ, Hamel E. Jiang JB, et al. Among authors: hamel e. J Med Chem. 1990 Jun;33(6):1721-8. doi: 10.1021/jm00168a029. J Med Chem. 1990. PMID: 2088342

10

Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.

Muzaffar A, Brossi A, Lin CM, Hamel E. Muzaffar A, et al. Among authors: hamel e. J Med Chem. 1990 Feb;33(2):567-71. doi: 10.1021/jm00164a015. J Med Chem. 1990. PMID: 2299625

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