Queener SF - Search Results

1

Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases.

Gangjee A, Mavandadi F, Queener SF, McGuire JJ. Gangjee A, et al. Among authors: queener sf. J Med Chem. 1995 Jun 9;38(12):2158-65. doi: 10.1021/jm00012a016. J Med Chem. 1995. PMID: 7783147

2

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.

Shah K, Queener S, Cody V, Pace J, Gangjee A. Shah K, et al. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1874-1880. doi: 10.1016/j.bmcl.2019.06.004. Epub 2019 Jun 4. Bioorg Med Chem Lett. 2019. PMID: 31176699 Free PMC article.

3

Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.

Gangjee A, Adair OO, Queener SF. Gangjee A, et al. Among authors: queener sf. J Med Chem. 2003 Nov 6;46(23):5074-82. doi: 10.1021/jm030312n. J Med Chem. 2003. PMID: 14584957

4

Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

Gangjee A, Lin X, Queener SF. Gangjee A, et al. Among authors: queener sf. J Med Chem. 2004 Jul 1;47(14):3689-92. doi: 10.1021/jm0306327. J Med Chem. 2004. PMID: 15214795

5

Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents.

Gangjee A, Yang J, Queener SF. Gangjee A, et al. Among authors: queener sf. Bioorg Med Chem. 2006 Dec 15;14(24):8341-51. doi: 10.1016/j.bmc.2006.09.008. Epub 2006 Sep 28. Bioorg Med Chem. 2006. PMID: 17010625 Free PMC article.

6

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.

Gangjee A, Zeng Y, Talreja T, McGuire JJ, Kisliuk RL, Queener SF. Gangjee A, et al. Among authors: queener sf. J Med Chem. 2007 Jun 28;50(13):3046-53. doi: 10.1021/jm070165j. Epub 2007 Jun 7. J Med Chem. 2007. PMID: 17552508 Free PMC article.

7

The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.

Gangjee A, Jain HD, Queener SF, Kisliuk RL. Gangjee A, et al. Among authors: queener sf. J Med Chem. 2008 Aug 14;51(15):4589-600. doi: 10.1021/jm800244v. Epub 2008 Jul 8. J Med Chem. 2008. PMID: 18605720 Free PMC article.

8

N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.

Gangjee A, Adair OO, Pagley M, Queener SF. Gangjee A, et al. Among authors: queener sf. J Med Chem. 2008 Oct 9;51(19):6195-200. doi: 10.1021/jm800694g. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771252 Free PMC article.

9

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.

Gangjee A, Li W, Lin L, Zeng Y, Ihnat M, Warnke LA, Green DW, Cody V, Pace J, Queener SF. Gangjee A, et al. Among authors: queener sf. Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. doi: 10.1016/j.bmc.2009.08.044. Epub 2009 Aug 22. Bioorg Med Chem. 2009. PMID: 19748785 Free PMC article.

10

2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.

Gangjee A, Jain HD, Phan J, Guo X, Queener SF, Kisliuk RL. Gangjee A, et al. Among authors: queener sf. Bioorg Med Chem. 2010 Jan 15;18(2):953-61. doi: 10.1016/j.bmc.2009.11.029. Epub 2009 Dec 26. Bioorg Med Chem. 2010. PMID: 20056546 Free PMC article.

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