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Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.
Baldanti F, Underwood MR, Stanat SC, Biron KK, Chou S, Sarasini A, Silini E, Gerna G. Baldanti F, et al. Among authors: stanat sc. J Virol. 1996 Mar;70(3):1390-5. doi: 10.1128/JVI.70.3.1390-1395.1996. J Virol. 1996. PMID: 8627655 Free PMC article.
Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.
Talarico CL, Burnette TC, Miller WH, Smith SL, Davis MG, Stanat SC, Ng TI, He Z, Coen DM, Roizman B, Biron KK. Talarico CL, et al. Among authors: stanat sc. Antimicrob Agents Chemother. 1999 Aug;43(8):1941-6. doi: 10.1128/AAC.43.8.1941. Antimicrob Agents Chemother. 1999. PMID: 10428917 Free PMC article.
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