Nichols AJ - Search Results

1

Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore.

Ku TW, Miller WH, Bondinell WE, Erhard KF, Keenan RM, Nichols AJ, Peishoff CE, Samanen JM, Wong AS, Huffman WF. Ku TW, et al. Among authors: nichols aj. J Med Chem. 1995 Jan 6;38(1):9-12. doi: 10.1021/jm00001a003. J Med Chem. 1995. PMID: 7837245 No abstract available.

2

Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides.

Peishoff CE, Ali FE, Bean JW, Calvo R, D'Ambrosio CA, Eggleston DS, Hwang SM, Kline TP, Koster PF, Nichols A, et al. Peishoff CE, et al. J Med Chem. 1992 Oct 16;35(21):3962-9. doi: 10.1021/jm00099a026. J Med Chem. 1992. PMID: 1433203

3

Design and synthesis of a C7 mimetic for the predicted gamma-turn conformation found in several constrained RGD antagonists.

Callahan JF, Bean JW, Burgess JL, Eggleston DS, Hwang SM, Kopple KD, Koster PF, Nichols A, Peishoff CE, Samanen JM, et al. Callahan JF, et al. J Med Chem. 1992 Oct 16;35(21):3970-2. doi: 10.1021/jm00099a027. J Med Chem. 1992. PMID: 1433204 No abstract available.

4

Potent, selective, orally active 3-oxo-1,4-benzodiazepine GPIIb/IIIa integrin antagonists.

Samanen JM, Ali FE, Barton LS, Bondinell WE, Burgess JL, Callahan JF, Calvo RR, Chen W, Chen L, Erhard K, Feuerstein G, Heys R, Hwang SM, Jakas DR, Keenan RM, Ku TW, Kwon C, Lee CP, Miller WH, Newlander KA, Nichols A, Parker M, Peishoff CE, Rhodes G, Ross S, Shu A, Simpson R, Takata D, Yellin TO, Uzsinskas I, Venslavsky JW, Yuan CK, Huffman WF. Samanen JM, et al. J Med Chem. 1996 Dec 6;39(25):4867-70. doi: 10.1021/jm960558a. J Med Chem. 1996. PMID: 8960544 No abstract available.

5

Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists.

Keenan RM, Callahan JF, Samanen JM, Bondinell WE, Calvo RR, Chen L, DeBrosse C, Eggleston DS, Haltiwanger RC, Hwang SM, Jakas DR, Ku TW, Miller WH, Newlander KA, Nichols A, Parker MF, Southhall LS, Uzinskas I, Vasko-Moser JA, Venslavsky JW, Wong AS, Huffman WF. Keenan RM, et al. J Med Chem. 1999 Feb 25;42(4):545-59. doi: 10.1021/jm980166z. J Med Chem. 1999. PMID: 10052962

6

Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation.

Ali FE, Bennett DB, Calvo RR, Elliott JD, Hwang SM, Ku TW, Lago MA, Nichols AJ, Romoff TT, Shah DH, et al. Ali FE, et al. Among authors: nichols aj. J Med Chem. 1994 Mar 18;37(6):769-80. doi: 10.1021/jm00032a009. J Med Chem. 1994. PMID: 8145226

7

Chemical approaches to improve the oral bioavailability of peptidergic molecules.

Samanen J, Wilson G, Smith PL, Lee CP, Bondinell W, Ku T, Rhodes G, Nichols A. Samanen J, et al. J Pharm Pharmacol. 1996 Feb;48(2):119-35. doi: 10.1111/j.2042-7158.1996.tb07111.x. J Pharm Pharmacol. 1996. PMID: 8935160 Review.

8

Development of GPIIb/IIIa antagonists as antithrombotic drugs.

Nichols AJ, Ruffolo RR Jr, Huffman WF, Poste G, Samanen J. Nichols AJ, et al. Trends Pharmacol Sci. 1992 Nov;13(11):413-7. doi: 10.1016/0165-6147(92)90126-q. Trends Pharmacol Sci. 1992. PMID: 1440877 Review.

9

The in vitro pharmacological profile of SK&F 106760, a novel GPIIB/IIIA antagonist.

Nichols AJ, Vasko JA, Valocik RE, Kopaciewicz LJ, Storer BL, Ali FE, Romoff T, Calvo R, Samanen JM. Nichols AJ, et al. Thromb Res. 1994 Jul 15;75(2):143-56. doi: 10.1016/0049-3848(94)90063-9. Thromb Res. 1994. PMID: 7974388

10

The in vivo pharmacological profile of the novel glycoprotein IIb/IIIa antagonist, SK&F 106760.

Nichols AJ, Vasko JA, Koster PF, Valocik RE, Rhodes GR, Miller-Stein C, Boppana V, Samanen JM. Nichols AJ, et al. J Pharmacol Exp Ther. 1994 Aug;270(2):614-21. J Pharmacol Exp Ther. 1994. PMID: 8071853

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

142 results

Search Page

Filters