Lessnick SL - Search Results

1

Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene.

Lessnick SL, Braun BS, Denny CT, May WA. Lessnick SL, et al. Oncogene. 1995 Feb 2;10(3):423-31. Oncogene. 1995. PMID: 7845667

2

Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis.

Braun BS, Frieden R, Lessnick SL, May WA, Denny CT. Braun BS, et al. Among authors: lessnick sl. Mol Cell Biol. 1995 Aug;15(8):4623-30. doi: 10.1128/MCB.15.8.4623. Mol Cell Biol. 1995. PMID: 7623854 Free PMC article.

3

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG.

Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. Sorensen PH, et al. Among authors: lessnick sl. Nat Genet. 1994 Feb;6(2):146-51. doi: 10.1038/ng0294-146. Nat Genet. 1994. PMID: 8162068

4

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.

May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, Hromas R, Denny CT. May WA, et al. Among authors: lessnick sl. Mol Cell Biol. 1993 Dec;13(12):7393-8. doi: 10.1128/mcb.13.12.7393-7398.1993. Mol Cell Biol. 1993. PMID: 8246959 Free PMC article.

5

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, Zucman J, Thomas G, Denny CT. May WA, et al. Among authors: lessnick sl. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5752-6. doi: 10.1073/pnas.90.12.5752. Proc Natl Acad Sci U S A. 1993. PMID: 8516324 Free PMC article.

6

GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance.

Luo W, Gangwal K, Sankar S, Boucher KM, Thomas D, Lessnick SL. Luo W, et al. Among authors: lessnick sl. Oncogene. 2009 Nov 19;28(46):4126-32. doi: 10.1038/onc.2009.262. Epub 2009 Aug 31. Oncogene. 2009. PMID: 19718047

7

Recent advances in the molecular pathogenesis of Ewing's sarcoma.

Toomey EC, Schiffman JD, Lessnick SL. Toomey EC, et al. Among authors: lessnick sl. Oncogene. 2010 Aug 12;29(32):4504-16. doi: 10.1038/onc.2010.205. Epub 2010 Jun 14. Oncogene. 2010. PMID: 20543858 Free PMC article. Review.

8

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

Sankar S, Bell R, Stephens B, Zhuo R, Sharma S, Bearss DJ, Lessnick SL. Sankar S, et al. Among authors: lessnick sl. Oncogene. 2013 Oct 17;32(42):5089-100. doi: 10.1038/onc.2012.525. Epub 2012 Nov 26. Oncogene. 2013. PMID: 23178492 Free PMC article.

9

Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.

Luo W, Xu C, Ayello J, Dela Cruz F, Rosenblum JM, Lessnick SL, Cairo MS. Luo W, et al. Among authors: lessnick sl. Oncogene. 2018 Feb 8;37(6):798-809. doi: 10.1038/onc.2017.378. Epub 2017 Oct 23. Oncogene. 2018. PMID: 29059150

10

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma.

Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. Boone MA, et al. Among authors: lessnick sl. Oncogene. 2021 Jul;40(29):4759-4769. doi: 10.1038/s41388-021-01876-5. Epub 2021 Jun 18. Oncogene. 2021. PMID: 34145397 Free PMC article.

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