Gribble A - Search Results

1

Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based inhibitors of ATP citrate lyase.

Dolle RE, Gribble A, Wilkes T, Kruse LI, Eggleston D, Saxty BA, Wells TN, Groot PH. Dolle RE, et al. Among authors: gribble a. J Med Chem. 1995 Feb 3;38(3):537-43. doi: 10.1021/jm00003a016. J Med Chem. 1995. PMID: 7853346

2

ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme.

Gribble AD, Dolle RE, Shaw A, McNair D, Novelli R, Novelli CE, Slingsby BP, Shah VP, Tew D, Saxty BA, Allen M, Groot PH, Pearce N, Yates J. Gribble AD, et al. J Med Chem. 1996 Aug 30;39(18):3569-84. doi: 10.1021/jm960167w. J Med Chem. 1996. PMID: 8784456

3

ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.

Gribble AD, Ife RJ, Shaw A, McNair D, Novelli CE, Bakewell S, Shah VP, Dolle RE, Groot PH, Pearce N, Yates J, Tew D, Boyd H, Ashman S, Eggleston DS, Haltiwanger RC, Okafo G. Gribble AD, et al. J Med Chem. 1998 Sep 10;41(19):3582-95. doi: 10.1021/jm980091z. J Med Chem. 1998. PMID: 9733484

4

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

Pearce NJ, Yates JW, Berkhout TA, Jackson B, Tew D, Boyd H, Camilleri P, Sweeney P, Gribble AD, Shaw A, Groot PH. Pearce NJ, et al. Among authors: gribble ad. Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):113-9. doi: 10.1042/bj3340113. Biochem J. 1998. PMID: 9693110 Free PMC article.

5

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.

Witherington J, Bordas V, Cooper DG, Forbes IT, Gribble AD, Ife RJ, Berkhout T, Gohil J, Groot PH. Witherington J, et al. Among authors: gribble ad. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2177-80. doi: 10.1016/s0960-894x(01)00397-3. Bioorg Med Chem Lett. 2001. PMID: 11514164

6

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

Berkhout TA, Blaney FE, Bridges AM, Cooper DG, Forbes IT, Gribble AD, Groot PH, Hardy A, Ife RJ, Kaur R, Moores KE, Shillito H, Willetts J, Witherington J. Berkhout TA, et al. Among authors: gribble ad. J Med Chem. 2003 Sep 11;46(19):4070-86. doi: 10.1021/jm030862l. J Med Chem. 2003. PMID: 12954060

7

Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K.

Fenwick AE, Gribble AD, Ife RJ, Stevens N, Witherington J. Fenwick AE, et al. Among authors: gribble ad. Bioorg Med Chem Lett. 2001 Jan 22;11(2):199-202. doi: 10.1016/s0960-894x(00)00627-2. Bioorg Med Chem Lett. 2001. PMID: 11206458

8

Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K.

Fenwick AE, Garnier B, Gribble AD, Ife RJ, Rawlings AD, Witherington J. Fenwick AE, et al. Among authors: gribble ad. Bioorg Med Chem Lett. 2001 Jan 22;11(2):195-8. doi: 10.1016/s0960-894x(00)00626-0. Bioorg Med Chem Lett. 2001. PMID: 11206457

9

Cyclic ketone inhibitors of the cysteine protease cathepsin K.

Marquis RW, Ru Y, Zeng J, Trout RE, LoCastro SM, Gribble AD, Witherington J, Fenwick AE, Garnier B, Tomaszek T, Tew D, Hemling ME, Quinn CJ, Smith WW, Zhao B, McQueney MS, Janson CA, D'Alessio K, Veber DF. Marquis RW, et al. Among authors: gribble ad. J Med Chem. 2001 Mar 1;44(5):725-36. doi: 10.1021/jm000320t. J Med Chem. 2001. PMID: 11262083

10

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

Smith DG, Gribble AD, Haigh D, Ife RJ, Lavery P, Skett P, Slingsby BP, Stacey R, Ward RW, West A. Smith DG, et al. Among authors: gribble ad. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3137-42. doi: 10.1016/s0960-894x(99)00539-9. Bioorg Med Chem Lett. 1999. PMID: 10560740

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