O'Briant K - Search Results

1

The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin.

Xu FJ, Boyer CM, Bae DS, Wu S, Greenwald M, O'Briant K, Yu YH, Mills GB, Bast RC Jr. Xu FJ, et al. Int J Cancer. 1994 Oct 15;59(2):242-7. doi: 10.1002/ijc.2910590217. Int J Cancer. 1994. PMID: 7927925

2

Elimination of clonogenic breast cancer cells from human bone marrow. A comparison of immunotoxin treatment with chemoimmunoseparation using 4-hydroperoxycyclophosphamide, monoclonal antibodies, and magnetic microspheres.

O'Briant KC, Shpall EJ, Houston LL, Peters WP, Bast RC Jr. O'Briant KC, et al. Cancer. 1991 Sep 15;68(6):1272-8. doi: 10.1002/1097-0142(19910915)68:6<1272::aid-cncr2820680616>3.0.co;2-l. Cancer. 1991. PMID: 1873781

3

The effect of antibodies and immunotoxins reactive with HER-2/neu on growth of ovarian and breast cancer cell lines.

Rodríguez GC, Boente MP, Berchuck A, Whitaker RS, O'Briant KC, Xu F, Bast RC Jr. Rodríguez GC, et al. Am J Obstet Gynecol. 1993 Jan;168(1 Pt 1):228-32. doi: 10.1016/s0002-9378(12)90918-7. Am J Obstet Gynecol. 1993. PMID: 8420332

4

Relative cytotoxic activity of immunotoxins reactive with different epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185.

Boyer CM, Pusztai L, Wiener JR, Xu FJ, Dean GS, Bast BS, O'Briant KC, Greenwald M, DeSombre KA, Bast RC Jr. Boyer CM, et al. Int J Cancer. 1999 Aug 12;82(4):525-31. doi: 10.1002/(sici)1097-0215(19990812)82:4<525::aid-ijc10>3.0.co;2-j. Int J Cancer. 1999. PMID: 10404066

5

A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines.

Crews JR, Maier LA, Yu YH, Hester S, O'Briant K, Leslie DS, DeSombre K, George SL, Boyer CM, Argon Y, et al. Crews JR, et al. Int J Cancer. 1992 Jul 9;51(5):772-9. doi: 10.1002/ijc.2910510518. Int J Cancer. 1992. PMID: 1351885

6

Cell surface density of p185(c-erbB-2) determines susceptibility to anti-p185(c-erbB-2)-ricin A chain (RTA) immunotoxin therapy alone and in combination with anti-p170(EGFR)-RTA in ovarian cancer cells.

Dean GS, Pusztai L, Xu FJ, O'Briant K, DeSombre K, Conaway M, Boyer CM, Mendelsohn J, Bast RC Jr. Dean GS, et al. Clin Cancer Res. 1998 Oct;4(10):2545-50. Clin Cancer Res. 1998. PMID: 9796989

7

Synergistic interaction between anti-p185HER-2 ricin A chain immunotoxins and radionuclide conjugates for inhibiting growth of ovarian and breast cancer cells that overexpress HER-2.

Xu F, Leadon SA, Yu Y, Boyer CM, O'Briant K, Ward K, McWatters A, Zhao X, Bae DS, DeSombre K, Zalutsky MR, Bast RC Jr. Xu F, et al. Clin Cancer Res. 2000 Aug;6(8):3334-41. Clin Cancer Res. 2000. PMID: 10955821

8

Alkylating agents and immunotoxins exert synergistic cytotoxic activity against ovarian cancer cells. Mechanism of action.

Lidor YJ, O'Briant KC, Xu FJ, Hamilton TC, Ozols RF, Bast RC Jr. Lidor YJ, et al. J Clin Invest. 1993 Nov;92(5):2440-7. doi: 10.1172/JCI116851. J Clin Invest. 1993. PMID: 8227359 Free PMC article.

9

Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.

Xu FJ, Stack S, Boyer C, O'Briant K, Whitaker R, Mills GB, Yu YH, Bast RC Jr. Xu FJ, et al. Clin Cancer Res. 1997 Sep;3(9):1629-34. Clin Cancer Res. 1997. PMID: 9815853

10

Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines.

Tyson FL, Boyer CM, Kaufman R, O'Briant K, Cram G, Crews JR, Soper JT, Daly L, Fowler WC Jr, Haskill JS, et al. Tyson FL, et al. Am J Obstet Gynecol. 1991 Sep;165(3):640-6. doi: 10.1016/0002-9378(91)90300-g. Am J Obstet Gynecol. 1991. PMID: 1679963

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