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Cure of mice with established metastatic friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-alpha 1 and herpes simplex thymidine kinase followed by ganciclovir.
Santodonato L, Ferrantini M, Gabriele L, Proietti E, Venditti M, Musiani P, Modesti A, Modica A, Lupton SD, Belardelli F. Santodonato L, et al. Among authors: ferrantini m. Hum Gene Ther. 1996 Jan;7(1):1-10. doi: 10.1089/hum.1996.7.1-1. Hum Gene Ther. 1996. PMID: 8825863
Type I consensus IFN (IFN-con1) gene transfer into KSHV/HHV-8-infected BCBL-1 cells causes inhibition of viral lytic cycle activation via induction of apoptosis and abrogates tumorigenicity in sCID mice.
D'Agostino G, Aricò E, Santodonato L, Venditti M, Sestili P, Masuelli L, Coletti A, Modesti A, Picchio G, Mosier DE, Ferrantini M, Belardelli F. D'Agostino G, et al. Among authors: ferrantini m. J Interferon Cytokine Res. 1999 Nov;19(11):1305-16. doi: 10.1089/107999099312984. J Interferon Cytokine Res. 1999. PMID: 10574624
Type I consensus interferon (CIFN) gene transfer into human melanoma cells up-regulates p53 and enhances cisplatin-induced apoptosis: implications for new therapeutic strategies with IFN-alpha.
Mecchia M, Matarrese P, Malorni W, D'Agostino G, Sestili P, Santini SM, Gauzzi MC, Venditti M, Mazzocchi A, Parmiani G, Belardelli F, Ferrantini M. Mecchia M, et al. Among authors: ferrantini m. Gene Ther. 2000 Jan;7(2):167-79. doi: 10.1038/sj.gt.3301059. Gene Ther. 2000. PMID: 10673721
Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response.
Santodonato L, D'Agostino G, Nisini R, Mariotti S, Monque DM, Spada M, Lattanzi L, Perrone MP, Andreotti M, Belardelli F, Ferrantini M. Santodonato L, et al. Among authors: ferrantini m. J Immunol. 2003 May 15;170(10):5195-202. doi: 10.4049/jimmunol.170.10.5195. J Immunol. 2003. PMID: 12734367
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