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Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.
Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A. Slater MJ, et al. Among authors: bravi g. J Med Chem. 2007 Mar 8;50(5):897-900. doi: 10.1021/jm061207r. Epub 2007 Feb 2. J Med Chem. 2007. PMID: 17269759
Discovery of biaryl inhibitors of H+/K+ ATPase.
Garton N, Bailey N, Bamford M, Demont E, Farre-Gutierrez I, Hutley G, Bravi G, Pickering P. Garton N, et al. Among authors: bravi g. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1049-54. doi: 10.1016/j.bmcl.2009.12.040. Epub 2009 Dec 21. Bioorg Med Chem Lett. 2010. PMID: 20053560
Global 3D-QSAR methods: MS-WHIM and autocorrelation.
Gancia E, Bravi G, Mascagni P, Zaliani A. Gancia E, et al. Among authors: bravi g. J Comput Aided Mol Des. 2000 Mar;14(3):293-306. doi: 10.1023/a:1008142124682. J Comput Aided Mol Des. 2000. PMID: 10756483
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.
Myatt JW, Healy MP, Bravi GS, Billinton A, Johnson CN, Matthews KL, Jandu KS, Meng W, Hersey A, Livermore DG, Douault CB, Witherington J, Bit RA, Rowedder JE, Brown JD, Clayton NM. Myatt JW, et al. Among authors: bravi gs. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4683-8. doi: 10.1016/j.bmcl.2010.05.026. Epub 2010 May 31. Bioorg Med Chem Lett. 2010. PMID: 20566291
33 results