Thummel KE - Search Results

1

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.

Kerr BM, Thummel KE, Wurden CJ, Klein SM, Kroetz DL, Gonzalez FJ, Levy RH. Kerr BM, et al. Among authors: thummel ke. Biochem Pharmacol. 1994 Jun 1;47(11):1969-79. doi: 10.1016/0006-2952(94)90071-x. Biochem Pharmacol. 1994. PMID: 8010982

2

Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants.

Tran A, Rey E, Pons G, Rousseau M, d'Athis P, Olive G, Mather GG, Bishop FE, Wurden CJ, Labroo R, Trager WF, Kunze KL, Thummel KE, Vincent JC, Gillardin JM, Lepage F, Levy RH. Tran A, et al. Among authors: thummel ke. Clin Pharmacol Ther. 1997 Nov;62(5):490-504. doi: 10.1016/S0009-9236(97)90044-8. Clin Pharmacol Ther. 1997. PMID: 9390105

3

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4.

Thummel KE, Lee CA, Kunze KL, Nelson SD, Slattery JT. Thummel KE, et al. Biochem Pharmacol. 1993 Apr 22;45(8):1563-9. doi: 10.1016/0006-2952(93)90295-8. Biochem Pharmacol. 1993. PMID: 8387297

4

Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.

Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K. Andersson T, et al. Clin Pharmacol Ther. 2005 Dec;78(6):559-81. doi: 10.1016/j.clpt.2005.08.013. Clin Pharmacol Ther. 2005. PMID: 16338273 Review. No abstract available.

5

In vitro metabolism of cyclosporine A by human kidney CYP3A5.

Dai Y, Iwanaga K, Lin YS, Hebert MF, Davis CL, Huang W, Kharasch ED, Thummel KE. Dai Y, et al. Among authors: thummel ke. Biochem Pharmacol. 2004 Nov 1;68(9):1889-902. doi: 10.1016/j.bcp.2004.07.012. Biochem Pharmacol. 2004. PMID: 15450954

6

Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients.

Sachdeo RC, Sachdeo SK, Levy RH, Streeter AJ, Bishop FE, Kunze KL, Mather GG, Roskos LK, Shen DD, Thummel KE, Trager WF, Curtin CR, Doose DR, Gisclon LG, Bialer M. Sachdeo RC, et al. Among authors: thummel ke. Epilepsia. 2002 Jul;43(7):691-6. doi: 10.1046/j.1528-1157.2002.41701.x. Epilepsia. 2002. PMID: 12102670 Free article.

7

Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study.

Zhao P, Ragueneau-Majlessi I, Zhang L, Strong JM, Reynolds KS, Levy RH, Thummel KE, Huang SM. Zhao P, et al. Among authors: thummel ke. J Clin Pharmacol. 2009 Mar;49(3):351-9. doi: 10.1177/0091270008331196. J Clin Pharmacol. 2009. PMID: 19246732

8

Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells.

Zheng XE, Wang Z, Liao MZ, Lin YS, Shuhart MC, Schuetz EG, Thummel KE. Zheng XE, et al. Among authors: thummel ke. Biochem Pharmacol. 2012 Aug 1;84(3):391-401. doi: 10.1016/j.bcp.2012.04.019. Epub 2012 May 4. Biochem Pharmacol. 2012. PMID: 22562045 Free PMC article.

9

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.

Lin YS, Dowling AL, Quigley SD, Farin FM, Zhang J, Lamba J, Schuetz EG, Thummel KE. Lin YS, et al. Among authors: thummel ke. Mol Pharmacol. 2002 Jul;62(1):162-72. doi: 10.1124/mol.62.1.162. Mol Pharmacol. 2002. PMID: 12065767

10

Metabolic fate of valproic acid in the rhesus monkey. Formation of a toxic metabolite, 2-n-propyl-4-pentenoic acid.

Rettenmeier AW, Gordon WP, Prickett KS, Levy RH, Lockard JS, Thummel KE, Baillie TA. Rettenmeier AW, et al. Among authors: thummel ke. Drug Metab Dispos. 1986 Jul-Aug;14(4):443-53. Drug Metab Dispos. 1986. PMID: 2873992

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