Gillies PJ - Search Results

1

Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans.

Hainer JW, Terry JG, Connell JM, Zyruk H, Jenkins RM, Shand DL, Gillies PJ, Livak KJ, Hunt TL, Crouse JR 3rd. Hainer JW, et al. Among authors: gillies pj. Clin Pharmacol Ther. 1994 Jul;56(1):65-74. doi: 10.1038/clpt.1994.102. Clin Pharmacol Ther. 1994. PMID: 8033496 Clinical Trial.

2

Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles.

Higley CA, Wilde RG, Maduskuie TP, Johnson AL, Pennev P, Billheimer JT, Robinson CS, Gillies PJ, Wexler RR. Higley CA, et al. Among authors: gillies pj. J Med Chem. 1994 Oct 14;37(21):3511-22. doi: 10.1021/jm00047a009. J Med Chem. 1994. PMID: 7932580

3

Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.

Maduskuie TP Jr, Wilde RG, Billheimer JT, Cromley DA, Germain S, Gillies PJ, Higley CA, Johnson AL, Pennev P, Shimshick EJ, et al. Maduskuie TP Jr, et al. Among authors: gillies pj. J Med Chem. 1995 Mar 31;38(7):1067-83. doi: 10.1021/jm00007a004. J Med Chem. 1995. PMID: 7707310

4

Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents.

Li HY, DeLucca I, Boswell GA, Billheimer JT, Drummond S, Gillies PJ, Robinson C. Li HY, et al. Among authors: gillies pj. Bioorg Med Chem. 1997 Jul;5(7):1345-61. doi: 10.1016/s0968-0896(97)00058-8. Bioorg Med Chem. 1997. PMID: 9377095

5

Gene expression of acyl-coenzyme-A:cholesterol-acyltransferase is upregulated in human monocytes during differentiation and foam cell formation.

Wang H, Germain SJ, Benfield PP, Gillies PJ. Wang H, et al. Among authors: gillies pj. Arterioscler Thromb Vasc Biol. 1996 Jun;16(6):809-14. doi: 10.1161/01.atv.16.6.809. Arterioscler Thromb Vasc Biol. 1996. PMID: 8640409

6

Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis: implications for drug discovery.

Gillies PJ, Robinson CS, Rathgeb KA. Gillies PJ, et al. Atherosclerosis. 1990 Aug;83(2-3):177-85. doi: 10.1016/0021-9150(90)90163-d. Atherosclerosis. 1990. PMID: 2242095

7

ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes.

Wilde RG, Billheimer JT, Germain SJ, Hausner EA, Meunier PC, Munzer DA, Stoltenborg JK, Gillies PJ, Burcham DL, Huang SM, Klaczkiewicz JD, Ko SS, Wexler RR. Wilde RG, et al. Among authors: gillies pj. Bioorg Med Chem. 1996 Sep;4(9):1493-513. doi: 10.1016/0968-0896(96)00143-5. Bioorg Med Chem. 1996. PMID: 8894107

8

Regulation of acyl-CoA:cholesterol acyltransferase activity in normal and atherosclerotic rabbit aortas: role of a cholesterol substrate pool.

Gillies PJ, Rathgeb KA, Perri MA, Robinson CS. Gillies PJ, et al. Exp Mol Pathol. 1986 Jun;44(3):329-39. doi: 10.1016/0014-4800(86)90046-8. Exp Mol Pathol. 1986. PMID: 3720921

9

Effect of lanthanum chloride on established atherosclerosis in the cholesterol-fed rabbit. Mitral valve as a site for assessment of treatment effects.

Gillies PJ, Robinson CS, Cockrell BY, Graepel GJ. Gillies PJ, et al. Arteriosclerosis. 1989 Mar-Apr;9(2):253-60. doi: 10.1161/01.atv.9.2.253. Arteriosclerosis. 1989. PMID: 2923582

10

Alterations in lipid metabolism and cellular morphology in the liver of female rats treated with ethmozine.

Vincent DR, Gillies PJ, Lee KP, Wood CK, Arthaud LE. Vincent DR, et al. Among authors: gillies pj. Toxicol Appl Pharmacol. 1988 Sep 30;95(3):456-63. doi: 10.1016/0041-008x(88)90363-8. Toxicol Appl Pharmacol. 1988. PMID: 3055426

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