Frye SV - Search Results

1

6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.

Frye SV, Haffner CD, Maloney PR, Mook RA Jr, Dorsey GF Jr, Hiner RN, Cribbs CM, Wheeler TN, Ray JA, Andrews RC, et al. Frye SV, et al. J Med Chem. 1994 Jul 22;37(15):2352-60. doi: 10.1021/jm00041a014. J Med Chem. 1994. PMID: 8057283

2

Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies.

Tian G, Mook RA Jr, Moss ML, Frye SV. Tian G, et al. Among authors: frye sv. Biochemistry. 1995 Oct 17;34(41):13453-9. doi: 10.1021/bi00041a024. Biochemistry. 1995. PMID: 7577933

3

Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.

Frye SV, Haffner CD, Maloney PR, Hiner RN, Dorsey GF, Noe RA, Unwalla RJ, Batchelor KW, Bramson HN, Stuart JD, et al. Frye SV, et al. J Med Chem. 1995 Jul 7;38(14):2621-7. doi: 10.1021/jm00014a015. J Med Chem. 1995. PMID: 7629802

4

6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.

Frye SV, Haffner CD, Maloney PR, Mook RA Jr, Dorsey GF Jr, Hiner RN, Batchelor KW, Bramson HN, Stuart JD, Schweiker SL, et al. Frye SV, et al. J Med Chem. 1993 Dec 24;36(26):4313-5. doi: 10.1021/jm00078a022. J Med Chem. 1993. PMID: 8277514 No abstract available.

5

Inhibition of human steroid 5alpha reductases type I and II by 6-aza-steroids: structural determinants of one-step vs two-step mechanism.

Moss ML, Kuzmic P, Stuart JD, Tian G, Peranteau AG, Frye SV, Kadwell SH, Kost TA, Overton LK, Patel IR. Moss ML, et al. Among authors: frye sv. Biochemistry. 1996 Mar 19;35(11):3457-64. doi: 10.1021/bi952472+. Biochemistry. 1996. PMID: 8639496

6

Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR.

Bramson HN, Hermann D, Batchelor KW, Lee FW, James MK, Frye SV. Bramson HN, et al. Among authors: frye sv. J Pharmacol Exp Ther. 1997 Sep;282(3):1496-502. J Pharmacol Exp Ther. 1997. PMID: 9316864

7

Discovery and development of GG745, a potent inhibitor of both isozymes of 5 alpha-reductase.

Frye SV, Bramson HN, Hermann DJ, Lee FW, Sinhababu AK, Tian G. Frye SV, et al. Pharm Biotechnol. 1998;11:393-422. doi: 10.1007/0-306-47384-4_17. Pharm Biotechnol. 1998. PMID: 9760689 Review. No abstract available.

8

The discovery of potent cRaf1 kinase inhibitors.

Lackey K, Cory M, Davis R, Frye SV, Harris PA, Hunter RN, Jung DK, McDonald OB, McNutt RW, Peel MR, Rutkowske RD, Veal JM, Wood ER. Lackey K, et al. Among authors: frye sv. Bioorg Med Chem Lett. 2000 Feb 7;10(3):223-6. doi: 10.1016/s0960-894x(99)00668-x. Bioorg Med Chem Lett. 2000. PMID: 10698440

9

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

Bramson HN, Corona J, Davis ST, Dickerson SH, Edelstein M, Frye SV, Gampe RT Jr, Harris PA, Hassell A, Holmes WD, Hunter RN, Lackey KE, Lovejoy B, Luzzio MJ, Montana V, Rocque WJ, Rusnak D, Shewchuk L, Veal JM, Walker DH, Kuyper LF. Bramson HN, et al. Among authors: frye sv. J Med Chem. 2001 Dec 6;44(25):4339-58. doi: 10.1021/jm010117d. J Med Chem. 2001. PMID: 11728181

10

A prodrug approach to the design of cRaf1 kinase inhibitors with improved cellular activity.

Wood E, Crosby RM, Dickerson S, Frye SV, Griffin R, Hunter R, Jung DK, McDonald OB, McNutt R, Mahony WB, Peel MR, Ray J, Lackey K. Wood E, et al. Among authors: frye sv. Anticancer Drug Des. 2001 Feb;16(1):1-6. Anticancer Drug Des. 2001. PMID: 11762640

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