Huang H - Search Results

1

Dual-action inhibitors of proteolytic enzymes: potential therapeutic agents for cystic fibrosis and related ailments.

Groutas WC, Huang H, Venkataraman R, Houser-Archield N, Epp JB. Groutas WC, et al. Among authors: huang h. Bioorg Med Chem. 1993 Oct;1(4):273-7. doi: 10.1016/s0968-0896(00)82132-x. Bioorg Med Chem. 1993. PMID: 8081858 No abstract available.

2

Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives.

Groutas WC, Houser-Archield N, Chong LS, Venkataraman R, Epp JB, Huang H, McClenahan JJ. Groutas WC, et al. Among authors: huang h. J Med Chem. 1993 Oct 15;36(21):3178-81. doi: 10.1021/jm00073a019. J Med Chem. 1993. PMID: 8230105

3

Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.

Groutas WC, Chong LS, Venkataraman R, Epp JB, Kuang RZ, Brubaker MJ, Houser-Archield N, Huang H, McClenahan JJ. Groutas WC, et al. Among authors: huang h. Biochem Biophys Res Commun. 1993 Aug 16;194(3):1491-9. doi: 10.1006/bbrc.1993.1993. Biochem Biophys Res Commun. 1993. PMID: 8352807

4

Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.

Groutas WC, Brubaker MJ, Chong LS, Venkataraman R, Huang H, Epp JB, Kuang R, Hoidal JR. Groutas WC, et al. Among authors: huang h. Bioorg Med Chem. 1995 Apr;3(4):375-81. doi: 10.1016/0968-0896(95)00024-b. Bioorg Med Chem. 1995. PMID: 8581420

5

Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3.

Groutas WC, Chong LS, Venkataraman R, Kuang R, Epp JB, Houser-Archield N, Huang H, Hoidal JR. Groutas WC, et al. Among authors: huang h. Arch Biochem Biophys. 1996 Aug 15;332(2):335-40. doi: 10.1006/abbi.1996.0350. Arch Biochem Biophys. 1996. PMID: 8806743

6

Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils.

Groutas WC, Huang H, Epp JB, Venkataraman R, McClenahan JJ, Tagusagawa F. Groutas WC, et al. Among authors: huang h. Biochim Biophys Acta. 1994 Nov 29;1227(3):130-6. doi: 10.1016/0925-4439(94)90087-6. Biochim Biophys Acta. 1994. PMID: 7986820

7

Derivatives of 3-alkyl-N-hydroxysuccinimide: probing the effect of structure on bioactivity toward human leukocyte elastase.

Groutas WC, Brubaker MJ, Chong LS, Epp JB, Huang H, Keller CE, McClenahan JJ, Givens RS, Singh R, Zandler ME, et al. Groutas WC, et al. Among authors: huang h. Drug Des Discov. 1994 Feb;11(2):149-57. Drug Des Discov. 1994. PMID: 8075302

8

Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.

Huang H, Martásek P, Roman LJ, Silverman RB. Huang H, et al. J Med Chem. 2000 Jul 27;43(15):2938-45. doi: 10.1021/jm000127z. J Med Chem. 2000. PMID: 10956202

Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang, H.; Martasek, P.; Roman, L. J.; Masters, B. S. S.; Silverman, R. B. J. Med. Chem. 1999, 42, 3147). ...

Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang, …

9

Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.

Wu R, Saab NH, Huang H, Wiest L, Pegg AE, Casero RA Jr, Woster PM. Wu R, et al. Among authors: huang h. Bioorg Med Chem. 1996 Jun;4(6):825-36. doi: 10.1016/0968-0896(96)00072-7. Bioorg Med Chem. 1996. PMID: 8818232 Free article.

10

Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase.

Huang H, Martásek P, Roman LJ, Silverman RB. Huang H, et al. J Enzyme Inhib. 2001;16(3):233-9. doi: 10.1080/14756360109162371. J Enzyme Inhib. 2001. PMID: 11697043

Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang H. et al. (1999) J. Med. Chem., 42, 3147). The most potent nNOS inhibitor among these compounds is L-ArgNO2-L-Dbu-NH2 (1) (Ki = 130 n …

Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang …

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