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Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.
Archer RH, Dykes C, Gerondelis P, Lloyd A, Fay P, Reichman RC, Bambara RA, Demeter LM. Archer RH, et al. Among authors: dykes c. J Virol. 2000 Sep;74(18):8390-401. doi: 10.1128/jvi.74.18.8390-8401.2000. J Virol. 2000. PMID: 10954539 Free PMC article.
The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in replication efficiency.
Wang J, Dykes C, Domaoal RA, Koval CE, Bambara RA, Demeter LM. Wang J, et al. Among authors: dykes c. Virology. 2006 May 10;348(2):462-74. doi: 10.1016/j.virol.2006.01.014. Epub 2006 Feb 28. Virology. 2006. PMID: 16504235 Free PMC article.
93 results