Bock MG - Search Results

1

1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor.

Williams PD, Anderson PS, Ball RG, Bock MG, Carroll L, Chiu SH, Clineschmidt BV, Culberson JC, Erb JM, Evans BE, et al. Williams PD, et al. Among authors: bock mg. J Med Chem. 1994 Mar 4;37(5):565-71. doi: 10.1021/jm00031a004. J Med Chem. 1994. PMID: 8126695

2

Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product.

Williams PD, Bock MG, Tung RD, Garsky VM, Perlow DS, Erb JM, Lundell GF, Gould NP, Whitter WL, Hoffman JB, et al. Williams PD, et al. Among authors: bock mg. J Med Chem. 1992 Oct 16;35(21):3905-18. doi: 10.1021/jm00099a019. J Med Chem. 1992. PMID: 1331448

3

Bradykinin agonist activity of a novel, potent oxytocin antagonist.

Pettibone DJ, Clineschmidt BV, Lis EV, Ransom RW, Totaro JA, Young GS, Bock MG, Freidinger RM, Veber DF, Williams PD. Pettibone DJ, et al. Among authors: bock mg. Eur J Pharmacol. 1991 Apr 24;196(3):233-7. doi: 10.1016/0014-2999(91)90435-s. Eur J Pharmacol. 1991. PMID: 1893911

4

Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.

Freidinger RM, Williams PD, Tung RD, Bock MG, Pettibone DJ, Clineschmidt BV, DiPardo RM, Erb JM, Garsky VM, Gould NP, et al. Freidinger RM, et al. Among authors: bock mg. J Med Chem. 1990 Jul;33(7):1843-5. doi: 10.1021/jm00169a001. J Med Chem. 1990. PMID: 2163451 No abstract available.

5

Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide.

Bock MG, DiPardo RM, Williams PD, Pettibone DJ, Clineschmidt BV, Ball RG, Veber DF, Freidinger RM. Bock MG, et al. J Med Chem. 1990 Sep;33(9):2321-3. doi: 10.1021/jm00171a003. J Med Chem. 1990. PMID: 2167976 No abstract available.

6

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists.

Evans BE, Rittle KE, Bock MG, DiPardo RM, Freidinger RM, Whitter WL, Lundell GF, Veber DF, Anderson PS, Chang RS, et al. Evans BE, et al. Among authors: bock mg. J Med Chem. 1988 Dec;31(12):2235-46. doi: 10.1021/jm00120a002. J Med Chem. 1988. PMID: 2848124

7

Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency.

Bock MG, DiPardo RM, Evans BE, Freidinger RM, Rittle KE, Payne LS, Boger J, Whitter WL, LaMont BI, Ulm EH, et al. Bock MG, et al. J Med Chem. 1988 Oct;31(10):1918-23. doi: 10.1021/jm00118a009. J Med Chem. 1988. PMID: 3050088

8

Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Veber DF, Freidinger RM, Chang RS, Lotti VJ. Bock MG, et al. J Med Chem. 1988 Jan;31(1):176-81. doi: 10.1021/jm00396a028. J Med Chem. 1988. PMID: 3336017

9

Nanomolar-affinity, non-peptide oxytocin receptor antagonists.

Evans BE, Lundell GF, Gilbert KF, Bock MG, Rittle KE, Carroll LA, Williams PD, Pawluczyk JM, Leighton JL, Young MB, et al. Evans BE, et al. Among authors: bock mg. J Med Chem. 1993 Dec 10;36(25):3993-4005. doi: 10.1021/jm00077a002. J Med Chem. 1993. PMID: 8258821

10

Development of 1,4-benzodiazepine cholecystokinin type B antagonists.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Whitter WL, Garsky VM, Gilbert KF, Leighton JL, Carson KL, Mellin EC, et al. Bock MG, et al. J Med Chem. 1993 Dec 24;36(26):4276-92. doi: 10.1021/jm00078a018. J Med Chem. 1993. PMID: 8277510

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