Takata Y - Search Results

1

Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase.

Pang L, Milarski KL, Ohmichi M, Takata Y, Olefsky JM, Saltiel AR. Pang L, et al. Among authors: takata y. J Biol Chem. 1994 Apr 8;269(14):10604-8. J Biol Chem. 1994. PMID: 8144649 Free article.

2

Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.

Takata Y, Webster NJ, Olefsky JM. Takata Y, et al. J Biol Chem. 1992 May 5;267(13):9065-70. J Biol Chem. 1992. PMID: 1577744 Free article.

Compared with wild type receptors, the Y/F2 receptor exhibited markedly enhanced sensitivity to insulin-stimulated DNA synthesis with normal insulin-stimulated glucose uptake (Takata, Y., Webster, N. ...The insulin sensitivity for phosphorylation of two subst …

Compared with wild type receptors, the Y/F2 receptor exhibited markedly enhanced sensitivity to insulin-stimulated DNA synthesis with …

3

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.

Takata Y, Webster NJ, Olefsky JM. Takata Y, et al. J Biol Chem. 1991 May 15;266(14):9135-9. J Biol Chem. 1991. PMID: 2026614 Free article.

4

Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

Draznin B, Chang L, Leitner JW, Takata Y, Olefsky JM. Draznin B, et al. Among authors: takata y. J Biol Chem. 1993 Sep 25;268(27):19998-20001. J Biol Chem. 1993. PMID: 8376360 Free article.

5

Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.

Kusari J, Takata Y, Hatada E, Freidenberg G, Kolterman O, Olefsky JM. Kusari J, et al. Among authors: takata y. J Biol Chem. 1991 Mar 15;266(8):5260-7. J Biol Chem. 1991. PMID: 2002058 Free article.

6

Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.

Sasaoka T, Takata Y, Kusari J, Anderson CM, Langlois WJ, Olefsky JM. Sasaoka T, et al. Among authors: takata y. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4379-83. doi: 10.1073/pnas.90.10.4379. Proc Natl Acad Sci U S A. 1993. PMID: 8506276 Free PMC article.

7

The insulin receptor C-terminus is involved in regulation of the receptor kinase activity.

Kaliman P, Baron V, Alengrin F, Takata Y, Webster NJ, Olefsky JM, Van Obberghen E. Kaliman P, et al. Among authors: takata y. Biochemistry. 1993 Sep 21;32(37):9539-44. doi: 10.1021/bi00088a004. Biochemistry. 1993. PMID: 7690586

8

Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.

Sasaoka T, Ishiki M, Sawa T, Ishihara H, Takata Y, Imamura T, Usui I, Olefsky JM, Kobayashi M. Sasaoka T, et al. Among authors: takata y. Endocrinology. 1996 Oct;137(10):4427-34. doi: 10.1210/endo.137.10.8828504. Endocrinology. 1996. PMID: 8828504

9

A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation.

Smith RM, Sasaoka T, Shah N, Takata Y, Kusari J, Olefsky JM, Jarett L. Smith RM, et al. Among authors: takata y. Endocrinology. 1993 Apr;132(4):1453-62. doi: 10.1210/endo.132.4.8462446. Endocrinology. 1993. PMID: 8462446

10

A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.

Seely BL, Reichart DR, Takata Y, Yip C, Olefsky JM. Seely BL, et al. Among authors: takata y. Endocrinology. 1995 Apr;136(4):1635-41. doi: 10.1210/endo.136.4.7895674. Endocrinology. 1995. PMID: 7895674

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