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Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth.
Carlberg M, Dricu A, Blegen H, Wang M, Hjertman M, Zickert P, Höög A, Larsson O. Carlberg M, et al. J Biol Chem. 1996 Jul 19;271(29):17453-62. doi: 10.1074/jbc.271.29.17453. J Biol Chem. 1996. PMID: 8663239 Free article.
Inhibition of N-linked glycosylation using tunicamycin causes cell death in malignant cells: role of down-regulation of the insulin-like growth factor 1 receptor in induction of apoptosis.
Dricu A, Carlberg M, Wang M, Larsson O. Dricu A, et al. Among authors: carlberg m. Cancer Res. 1997 Feb 1;57(3):543-8. Cancer Res. 1997. PMID: 9012488
These mechanisms, although still not fully understood, involve an elevation of [Ca2+]i (M. Carlberg et al., Carcinogenesis, 17: 2589-2596, 1996). In contrast, in melanoma cells, TM has to be present continuously for 24-48 h to elicit apoptosis. ...
These mechanisms, although still not fully understood, involve an elevation of [Ca2+]i (M. Carlberg et al., Carcinogenesis, 17 …
161 results