Thornton TJ - Search Results

1

Synthesis and cytotoxicity of potential tumor-inhibitory analogues of trimelamol (2,4,6-tris[(hydroxymethyl)methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl.

Jarman M, Coley HM, Judson IR, Thornton TJ, Wilman DE, Abel G, Rutty CJ. Jarman M, et al. Among authors: thornton tj. J Med Chem. 1993 Dec 24;36(26):4195-200. doi: 10.1021/jm00078a008. J Med Chem. 1993. PMID: 8277501

2

Stable analogues of the antitumour agent trimelamol retain in vitro cytotoxicity in drug-sensitive and resistant rodent and human cell lines.

Coley HM, Jarman M, Brooks N, Thornton TJ, Judson IR. Coley HM, et al. Among authors: thornton tj. Eur J Cancer. 1994;30A(12):1827-36. doi: 10.1016/0959-8049(94)00323-w. Eur J Cancer. 1994. PMID: 7880614

3

The synthesis and thymidylate synthase inhibitory activity of L-gamma-L-linked dipeptide and L-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).

Bisset GM, Bavetsias V, Thornton TJ, Pawelczak K, Calvert AH, Hughes LR, Jackman AL. Bisset GM, et al. Among authors: thornton tj. J Med Chem. 1994 Sep 30;37(20):3294-302. doi: 10.1021/jm00046a014. J Med Chem. 1994. PMID: 7932557

4

Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.

Thornton TJ, Jackman AL, Marsham PR, O'Connor BM, Bishop JA, Calvert AH. Thornton TJ, et al. J Med Chem. 1992 Jun 12;35(12):2321-7. doi: 10.1021/jm00090a024. J Med Chem. 1992. PMID: 1613755

5

Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.

Thornton TJ, Jones TR, Jackman AL, Flinn A, O'Connor BM, Warner P, Calvert AH. Thornton TJ, et al. J Med Chem. 1991 Mar;34(3):978-84. doi: 10.1021/jm00107a015. J Med Chem. 1991. PMID: 2002476

6

Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.

Jackman AL, Marsham PR, Thornton TJ, Bishop JA, O'Connor BM, Hughes LR, Calvert AH, Jones TR. Jackman AL, et al. Among authors: thornton tj. J Med Chem. 1990 Nov;33(11):3067-71. doi: 10.1021/jm00173a025. J Med Chem. 1990. PMID: 2231607

7

Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.

Jones TR, Thornton TJ, Flinn A, Jackman AL, Newell DR, Calvert AH. Jones TR, et al. Among authors: thornton tj. J Med Chem. 1989 Apr;32(4):847-52. doi: 10.1021/jm00124a018. J Med Chem. 1989. PMID: 2704030

8

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).

Bavetsias V, Jackman AL, Thornton TJ, Pawelczak K, Boyle FT, Bisset GM. Bavetsias V, et al. Among authors: thornton tj. Adv Exp Med Biol. 1993;338:593-6. doi: 10.1007/978-1-4615-2960-6_121. Adv Exp Med Biol. 1993. PMID: 8304188 No abstract available.

9

Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.

Marsham PR, Jackman AL, Oldfield J, Hughes LR, Thornton TJ, Bisset GM, O'Connor BM, Bishop JA, Calvert AH. Marsham PR, et al. Among authors: thornton tj. J Med Chem. 1990 Nov;33(11):3072-8. doi: 10.1021/jm00173a026. J Med Chem. 1990. PMID: 2231608

10

A strategy for the design of membrane-permeable folypoly-gamma-glutamate synthetase inhibitors: "bay-region"-substituted 2-desamino-2-methyl-5,8-dideazafolate analogs.

Sanghani PC, Jackman A, Evans VR, Thornton T, Hughes L, Calvert AH, Moran RG. Sanghani PC, et al. Mol Pharmacol. 1994 Feb;45(2):341-51. Mol Pharmacol. 1994. PMID: 8114682

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