8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.
Ciardiello F, Tortora G, Kim N, Clair T, Ally S, Salomon DS, Cho-Chung YS.
Ciardiello F, et al. Among authors: tortora g.
J Biol Chem. 1990 Jan 15;265(2):1016-20.
J Biol Chem. 1990.
PMID: 1688548
Free article.
Differential regulation of the regulatory subunits of cAMP-dependent protein kinase isozymes correlates with the growth inhibitory effect of site-selective 8-Cl-cAMP demonstrated in cancer cell lines (Ally, S., Tortora, G., Clair, T., Grieco, D., Merlo, G., K …
Differential regulation of the regulatory subunits of cAMP-dependent protein kinase isozymes correlates with the growth inhibitory effect of …