Heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells. Comparison of the effects of heparin and modified heparins.
Ashikari-Hada S, Habuchi H, Kariya Y, Kimata K.
Ashikari-Hada S, et al. Among authors: kimata k.
J Biol Chem. 2005 Sep 9;280(36):31508-15. doi: 10.1074/jbc.M414581200. Epub 2005 Jul 15.
J Biol Chem. 2005.
PMID: 16027124
Free article.
We reported previously that heparin has an affinity for VEGF165, the major isoform of VEGF, whereas 2-O-desulfated heparin and 6-O-desulfated heparin have weak but significant affinity (Ashikari-Hada, S., Habuchi, H., Kariya, Y., Itoh, N., Reddi, A. H., and Kimata, K …
We reported previously that heparin has an affinity for VEGF165, the major isoform of VEGF, whereas 2-O-desulfated heparin and 6-O-desulfate …