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XB596, a promising bis-naphthalimide anti-cancer agent.
Chen SF, Behrens DL, Behrens CH, Czerniak PM, Dexter DL, Dusak BL, Fredericks JR, Gale KC, Gross JL, Jiang JB, et al. Chen SF, et al. Among authors: behrens ch. Anticancer Drugs. 1993 Aug;4(4):447-57. doi: 10.1097/00001813-199308000-00005. Anticancer Drugs. 1993. PMID: 8400347
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
Kirshenbaum MR, Chen SF, Behrens CH, Papp LM, Stafford MM, Sun JH, Behrens DL, Fredericks JR, Polkus ST, Sipple P, et al. Kirshenbaum MR, et al. Among authors: behrens ch. Cancer Res. 1994 Apr 15;54(8):2199-206. Cancer Res. 1994. PMID: 8174127
Preclinical antitumor activity of XK469 (NSC 656889).
LoRusso PM, Parchment R, Demchik L, Knight J, Polin L, Dzubow J, Behrens C, Harrison B, Trainor G, Corbett TH. LoRusso PM, et al. Invest New Drugs. 1998-1999;16(4):287-96. doi: 10.1023/a:1006206814025. Invest New Drugs. 1998. PMID: 10426660