Denis D - Search Results

1

Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.

Hutchinson JH, Riendeau D, Brideau C, Chan C, Delorme D, Denis D, Falgueyret JP, Fortin R, Guay J, Hamel P, et al. Hutchinson JH, et al. Among authors: denis d. J Med Chem. 1993 Sep 17;36(19):2771-87. doi: 10.1021/jm00071a008. J Med Chem. 1993. PMID: 8410991

2

Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.

Lau CK, Bélanger PC, Dufresne C, Scheigetz J, Therien M, Fitzsimmons B, Young RN, Ford-Hutchinson AW, Riendeau D, Denis D, et al. Lau CK, et al. Among authors: denis d. J Med Chem. 1992 Apr 3;35(7):1299-318. doi: 10.1021/jm00085a019. J Med Chem. 1992. PMID: 1313879

3

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.

Brideau C, Chan C, Charleson S, Denis D, Evans JF, Ford-Hutchinson AW, Fortin R, Gillard JW, Guay J, Guévremont D, et al. Brideau C, et al. Among authors: denis d. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807. doi: 10.1139/y92-107. Can J Physiol Pharmacol. 1992. PMID: 1330258

4

Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.

Denis D, Falgueyret JP, Riendeau D, Abramovitz M. Denis D, et al. J Biol Chem. 1991 Mar 15;266(8):5072-9. J Biol Chem. 1991. PMID: 1848236 Free article.

5

Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization.

Falgueyret JP, Denis D, Macdonald D, Hutchinson JH, Riendeau D. Falgueyret JP, et al. Among authors: denis d. Biochemistry. 1995 Oct 17;34(41):13603-11. doi: 10.1021/bi00041a040. Biochemistry. 1995. PMID: 7577949

6

Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions.

Percival MD, Denis D, Riendeau D, Gresser MJ. Percival MD, et al. Among authors: denis d. Eur J Biochem. 1992 Nov 15;210(1):109-17. doi: 10.1111/j.1432-1033.1992.tb17397.x. Eur J Biochem. 1992. PMID: 1446663 Free article.

7

Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation.

Riendeau D, Denis D, Choo LY, Nathaniel DJ. Riendeau D, et al. Among authors: denis d. Biochem J. 1989 Oct 15;263(2):565-72. doi: 10.1042/bj2630565. Biochem J. 1989. PMID: 2512907 Free PMC article.

8

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.

Gillard J, Ford-Hutchinson AW, Chan C, Charleson S, Denis D, Foster A, Fortin R, Leger S, McFarlane CS, Morton H, et al. Gillard J, et al. Among authors: denis d. Can J Physiol Pharmacol. 1989 May;67(5):456-64. doi: 10.1139/y89-073. Can J Physiol Pharmacol. 1989. PMID: 2548691

9

Activation of 5-lipoxygenase by guanosine 5'-O-(3-thiotriphosphate) and other nucleoside phosphorothioates: redox properties of thionucleotide analogs.

Denis D, Choo LY, Riendeau D. Denis D, et al. Arch Biochem Biophys. 1989 Sep;273(2):592-6. doi: 10.1016/0003-9861(89)90519-5. Arch Biochem Biophys. 1989. PMID: 2549876

10

Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles.

De Carolis E, Denis D, Riendeau D. De Carolis E, et al. Among authors: denis d. Eur J Biochem. 1996 Jan 15;235(1-2):416-23. doi: 10.1111/j.1432-1033.1996.00416.x. Eur J Biochem. 1996. PMID: 8631361 Free article.

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