Keenan RM - Search Results

1

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.

Keenan RM, Weinstock J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Hill DT, Morgan TM, Samanen JM, Peishoff CE, et al. Keenan RM, et al. J Med Chem. 1993 Jun 25;36(13):1880-92. doi: 10.1021/jm00065a011. J Med Chem. 1993. PMID: 8515425

2

Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.

Keenan RM, Weinstock J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Hill DT, Morgan TM, Samanen JM, Hempel J, et al. Keenan RM, et al. J Med Chem. 1992 Oct 16;35(21):3858-72. doi: 10.1021/jm00099a013. J Med Chem. 1992. PMID: 1433195

3

Characterization of renal angiotensin II receptors using subtype selective antagonists.

Edwards RM, Stack EJ, Weidley EF, Aiyar N, Keenan RM, Hill DT, Weinstock J. Edwards RM, et al. Among authors: keenan rm. J Pharmacol Exp Ther. 1992 Mar;260(3):933-8. J Pharmacol Exp Ther. 1992. PMID: 1545405

4

1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.

Weinstock J, Keenan RM, Samanen J, Hempel J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Gleason JG, Hill DT, et al. Weinstock J, et al. Among authors: keenan rm. J Med Chem. 1991 Apr;34(4):1514-7. doi: 10.1021/jm00108a043. J Med Chem. 1991. PMID: 2016730 No abstract available.

5

Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore.

Ku TW, Miller WH, Bondinell WE, Erhard KF, Keenan RM, Nichols AJ, Peishoff CE, Samanen JM, Wong AS, Huffman WF. Ku TW, et al. Among authors: keenan rm. J Med Chem. 1995 Jan 6;38(1):9-12. doi: 10.1021/jm00001a003. J Med Chem. 1995. PMID: 7837245 No abstract available.

6

Potent, selective, orally active 3-oxo-1,4-benzodiazepine GPIIb/IIIa integrin antagonists.

Samanen JM, Ali FE, Barton LS, Bondinell WE, Burgess JL, Callahan JF, Calvo RR, Chen W, Chen L, Erhard K, Feuerstein G, Heys R, Hwang SM, Jakas DR, Keenan RM, Ku TW, Kwon C, Lee CP, Miller WH, Newlander KA, Nichols A, Parker M, Peishoff CE, Rhodes G, Ross S, Shu A, Simpson R, Takata D, Yellin TO, Uzsinskas I, Venslavsky JW, Yuan CK, Huffman WF. Samanen JM, et al. Among authors: keenan rm. J Med Chem. 1996 Dec 6;39(25):4867-70. doi: 10.1021/jm960558a. J Med Chem. 1996. PMID: 8960544 No abstract available.

7

Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists.

Keenan RM, Miller WH, Kwon C, Ali FE, Callahan JF, Calvo RR, Hwang SM, Kopple KD, Peishoff CE, Samanen JM, Wong AS, Yuan CK, Huffman WF. Keenan RM, et al. J Med Chem. 1997 Jul 18;40(15):2289-92. doi: 10.1021/jm970205r. J Med Chem. 1997. PMID: 9240343 No abstract available.

8

Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists.

Keenan RM, Callahan JF, Samanen JM, Bondinell WE, Calvo RR, Chen L, DeBrosse C, Eggleston DS, Haltiwanger RC, Hwang SM, Jakas DR, Ku TW, Miller WH, Newlander KA, Nichols A, Parker MF, Southhall LS, Uzinskas I, Vasko-Moser JA, Venslavsky JW, Wong AS, Huffman WF. Keenan RM, et al. J Med Chem. 1999 Feb 25;42(4):545-59. doi: 10.1021/jm980166z. J Med Chem. 1999. PMID: 10052962

9

Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.

Edwards RM, Aiyar N, Ohlstein EH, Weidley EF, Griffin E, Ezekiel M, Keenan RM, Ruffolo RR, Weinstock J. Edwards RM, et al. Among authors: keenan rm. J Pharmacol Exp Ther. 1992 Jan;260(1):175-81. J Pharmacol Exp Ther. 1992. PMID: 1309870

10

Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model.

Keenan RM, Lago MA, Miller WH, Ali FE, Cousins RD, Hall LB, Hwang SM, Jakas DR, Kwon C, Louden C, Nguyen TT, Ohlstein EH, Rieman DJ, Ross ST, Samanen JM, Smith BR, Stadel J, Takata DT, Vickery L, Yuan CC, Yue TL. Keenan RM, et al. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3171-6. doi: 10.1016/s0960-894x(98)00556-3. Bioorg Med Chem Lett. 1998. PMID: 9873697

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