Samanen JM - Search Results

1

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.

Keenan RM, Weinstock J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Hill DT, Morgan TM, Samanen JM, Peishoff CE, et al. Keenan RM, et al. Among authors: samanen jm. J Med Chem. 1993 Jun 25;36(13):1880-92. doi: 10.1021/jm00065a011. J Med Chem. 1993. PMID: 8515425

2

1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.

Weinstock J, Keenan RM, Samanen J, Hempel J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Gleason JG, Hill DT, et al. Weinstock J, et al. J Med Chem. 1991 Apr;34(4):1514-7. doi: 10.1021/jm00108a043. J Med Chem. 1991. PMID: 2016730 No abstract available.

3

Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.

Keenan RM, Weinstock J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Hill DT, Morgan TM, Samanen JM, Hempel J, et al. Keenan RM, et al. Among authors: samanen jm. J Med Chem. 1992 Oct 16;35(21):3858-72. doi: 10.1021/jm00099a013. J Med Chem. 1992. PMID: 1433195

4

Design and synthesis of a C7 mimetic for the predicted gamma-turn conformation found in several constrained RGD antagonists.

Callahan JF, Bean JW, Burgess JL, Eggleston DS, Hwang SM, Kopple KD, Koster PF, Nichols A, Peishoff CE, Samanen JM, et al. Callahan JF, et al. Among authors: samanen jm. J Med Chem. 1992 Oct 16;35(21):3970-2. doi: 10.1021/jm00099a027. J Med Chem. 1992. PMID: 1433204 No abstract available.

5

Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore.

Ku TW, Miller WH, Bondinell WE, Erhard KF, Keenan RM, Nichols AJ, Peishoff CE, Samanen JM, Wong AS, Huffman WF. Ku TW, et al. Among authors: samanen jm. J Med Chem. 1995 Jan 6;38(1):9-12. doi: 10.1021/jm00001a003. J Med Chem. 1995. PMID: 7837245 No abstract available.

6

Potent, selective, orally active 3-oxo-1,4-benzodiazepine GPIIb/IIIa integrin antagonists.

Samanen JM, Ali FE, Barton LS, Bondinell WE, Burgess JL, Callahan JF, Calvo RR, Chen W, Chen L, Erhard K, Feuerstein G, Heys R, Hwang SM, Jakas DR, Keenan RM, Ku TW, Kwon C, Lee CP, Miller WH, Newlander KA, Nichols A, Parker M, Peishoff CE, Rhodes G, Ross S, Shu A, Simpson R, Takata D, Yellin TO, Uzsinskas I, Venslavsky JW, Yuan CK, Huffman WF. Samanen JM, et al. J Med Chem. 1996 Dec 6;39(25):4867-70. doi: 10.1021/jm960558a. J Med Chem. 1996. PMID: 8960544 No abstract available.

7

Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists.

Keenan RM, Miller WH, Kwon C, Ali FE, Callahan JF, Calvo RR, Hwang SM, Kopple KD, Peishoff CE, Samanen JM, Wong AS, Yuan CK, Huffman WF. Keenan RM, et al. Among authors: samanen jm. J Med Chem. 1997 Jul 18;40(15):2289-92. doi: 10.1021/jm970205r. J Med Chem. 1997. PMID: 9240343 No abstract available.

8

Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists.

Keenan RM, Callahan JF, Samanen JM, Bondinell WE, Calvo RR, Chen L, DeBrosse C, Eggleston DS, Haltiwanger RC, Hwang SM, Jakas DR, Ku TW, Miller WH, Newlander KA, Nichols A, Parker MF, Southhall LS, Uzinskas I, Vasko-Moser JA, Venslavsky JW, Wong AS, Huffman WF. Keenan RM, et al. Among authors: samanen jm. J Med Chem. 1999 Feb 25;42(4):545-59. doi: 10.1021/jm980166z. J Med Chem. 1999. PMID: 10052962

9

Potent angiotensin II antagonists with non-beta-branched amino acids in position 5.

Samanen J, Narindray D, Cash T, Brandeis E, Adams W Jr, Yellin T, Eggleston D, DeBrosse C, Regoli D. Samanen J, et al. J Med Chem. 1989 Feb;32(2):466-72. doi: 10.1021/jm00122a030. J Med Chem. 1989. PMID: 2913307

10

Characterization of bovine ovary angiotensin II receptors using subtype-selective antagonists.

Aiyar N, Griffin E, Edwards R, Weinstock J, Samanen J, Nambi P. Aiyar N, et al. Pharmacology. 1993;46(1):1-8. doi: 10.1159/000139022. Pharmacology. 1993. PMID: 8434027

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