Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.
Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR.
Hollander AP, et al.
J Clin Invest. 1995 Dec;96(6):2859-69. doi: 10.1172/JCI118357.
J Clin Invest. 1995.
PMID: 8675657
Free PMC article.
Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage in osteoarthritis (OA) has recently been quantitated immunochemically (Hollander, A.P., T.F. Heathfield, C. Webber, Y. Iwata, R. Bourne, C. Rorabeck, and A.R. ...
Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage in osteoarthritis (OA) has recently been quantitated immunoc …