Luzzio MJ - Search Results

1

Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin.

Lackey K, Sternbach DD, Croom DK, Emerson DL, Evans MG, Leitner PL, Luzzio MJ, McIntyre G, Vuong A, Yates J, Besterman JM. Lackey K, et al. Among authors: luzzio mj. J Med Chem. 1996 Feb 2;39(3):713-9. doi: 10.1021/jm950507y. J Med Chem. 1996. PMID: 8576914

2

Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.

Uehling DE, Nanthakumar SS, Croom D, Emerson DL, Leitner PP, Luzzio MJ, McIntyre G, Morton B, Profeta S, Sisco J, et al. Uehling DE, et al. Among authors: luzzio mj. J Med Chem. 1995 Mar 31;38(7):1106-18. doi: 10.1021/jm00007a008. J Med Chem. 1995. PMID: 7707314

3

In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues.

Emerson DL, Besterman JM, Brown HR, Evans MG, Leitner PP, Luzzio MJ, Shaffer JE, Sternbach DD, Uehling D, Vuong A. Emerson DL, et al. Among authors: luzzio mj. Cancer Res. 1995 Feb 1;55(3):603-9. Cancer Res. 1995. PMID: 7834631

4

Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.

Luzzio MJ, Besterman JM, Emerson DL, Evans MG, Lackey K, Leitner PL, McIntyre G, Morton B, Myers PL, Peel M, et al. Luzzio MJ, et al. J Med Chem. 1995 Feb 3;38(3):395-401. doi: 10.1021/jm00003a001. J Med Chem. 1995. PMID: 7853331

5

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

Bramson HN, Corona J, Davis ST, Dickerson SH, Edelstein M, Frye SV, Gampe RT Jr, Harris PA, Hassell A, Holmes WD, Hunter RN, Lackey KE, Lovejoy B, Luzzio MJ, Montana V, Rocque WJ, Rusnak D, Shewchuk L, Veal JM, Walker DH, Kuyper LF. Bramson HN, et al. Among authors: luzzio mj. J Med Chem. 2001 Dec 6;44(25):4339-58. doi: 10.1021/jm010117d. J Med Chem. 2001. PMID: 11728181

6

Novel 1,3-disubstituted-5,10-dihydro-5,10-dioxo-1H-benzo[g] isochromene-3 carboxamides as potent antitumor agents.

Wang W, Li T, Milburn R, Yates J, Hinnant E, Luzzio MJ, Noble SA, Attardo G. Wang W, et al. Among authors: luzzio mj. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1579-84. doi: 10.1016/s0960-894x(98)00274-1. Bioorg Med Chem Lett. 1998. PMID: 9873394

7

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.

Davis ST, Benson BG, Bramson HN, Chapman DE, Dickerson SH, Dold KM, Eberwein DJ, Edelstein M, Frye SV, Gampe RT Jr, Griffin RJ, Harris PA, Hassell AM, Holmes WD, Hunter RN, Knick VB, Lackey K, Lovejoy B, Luzzio MJ, Murray D, Parker P, Rocque WJ, Shewchuk L, Veal JM, Walker DH, Kuyper LF. Davis ST, et al. Among authors: luzzio mj. Science. 2001 Jan 5;291(5501):134-7. doi: 10.1126/science.291.5501.134. Science. 2001. Retraction in: Science. 2002 Dec 20;298(5602):2327. doi: 10.1126/science.298.5602.2327b PMID: 11141566 Retracted.

8

Antitumor efficacy, pharmacokinetics, and biodistribution of NX 211: a low-clearance liposomal formulation of lurtotecan.

Emerson DL, Bendele R, Brown E, Chiang S, Desjardins JP, Dihel LC, Gill SC, Hamilton M, LeRay JD, Moon-McDermott L, Moynihan K, Richardson FC, Tomkinson B, Luzzio MJ, Baccanari D. Emerson DL, et al. Among authors: luzzio mj. Clin Cancer Res. 2000 Jul;6(7):2903-12. Clin Cancer Res. 2000. PMID: 10914740

9

Encapsulation of the topoisomerase I inhibitor GL147211C in pegylated (STEALTH) liposomes: pharmacokinetics and antitumor activity in HT29 colon tumor xenografts.

Colbern GT, Dykes DJ, Engbers C, Musterer R, Hiller A, Pegg E, Saville R, Weng S, Luzzio M, Uster P, Amantea M, Working PK. Colbern GT, et al. Clin Cancer Res. 1998 Dec;4(12):3077-82. Clin Cancer Res. 1998. PMID: 9865923

10

Design of selective, ATP-competitive inhibitors of Akt.

Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J. Freeman-Cook KD, et al. Among authors: luzzio mj. J Med Chem. 2010 Jun 24;53(12):4615-22. doi: 10.1021/jm1003842. J Med Chem. 2010. PMID: 20481595

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