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Nonpeptidic HIV protease inhibitors: 4-hydroxy-pyran-2-one inhibitors with functional tethers to P1 phenyl ring to reach S3 pocket of the enzyme.
Vara Prasad J, Tummino PJ, Ferguson D, Saunders J, Vander Roest S, McQuade TJ, Heldsinger A, Reyner EL, Stewart BH, Guttendorf RJ, Para KS, Lunney EA, Gracheck SJ, Domagala JM. Vara Prasad J, et al. Among authors: para ks. Biochem Biophys Res Commun. 1996 Apr 25;221(3):815-20. doi: 10.1006/bbrc.1996.0679. Biochem Biophys Res Commun. 1996. PMID: 8630044
Nonpeptidic potent HIV-1 protease inhibitors.
Prasad JV, Lunney EA, Para KS, Tummino PJ, Ferguson D, Hupe D, Domagala JM, Erickson JW. Prasad JV, et al. Among authors: para ks. Drug Des Discov. 1996 Apr;13(3-4):15-28. Drug Des Discov. 1996. PMID: 8874041 Review.
Discovery and optimization of nonpeptide HIV-1 protease inhibitors.
Tummino PJ, Prasad JV, Ferguson D, Nouhan C, Graham N, Domagala JM, Ellsworth E, Gajda C, Hagen SE, Lunney EA, Para KS, Tait BD, Pavlovsky A, Erickson JW, Gracheck S, McQuade TJ, Hupe DJ. Tummino PJ, et al. Among authors: para ks. Bioorg Med Chem. 1996 Sep;4(9):1401-10. doi: 10.1016/0968-0896(96)00134-4. Bioorg Med Chem. 1996. PMID: 8894098
Design of peptidomimetic ligands for the pp60src SH2 domain.
Plummer MS, Lunney EA, Para KS, Shahripour A, Stankovic CJ, Humblet C, Fergus JH, Marks JS, Herrera R, Hubbell S, Saltiel A, Sawyer TK. Plummer MS, et al. Among authors: para ks. Bioorg Med Chem. 1997 Jan;5(1):41-7. doi: 10.1016/s0968-0896(96)00200-3. Bioorg Med Chem. 1997. PMID: 9043656 No abstract available.
Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones.
Galatsis P, Caprathe B, Downing D, Gilmore J, Harter W, Hays S, Kostlan C, Linn K, Lunney E, Para K, Thomas A, Warmus J, Allen H, Brady K, Talanian R, Walker N. Galatsis P, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5089-94. doi: 10.1016/j.bmcl.2010.07.031. Epub 2010 Jul 11. Bioorg Med Chem Lett. 2010. PMID: 20674352
Demoralization in Parkinson disease.
Koo BB, Chow CA, Shah DR, Khan FH, Steinberg B, Derlein D, Nalamada K, Para KS, Kakade VM, Patel AS, de Figueiredo JM, Louis ED. Koo BB, et al. Among authors: para ks. Neurology. 2018 May 1;90(18):e1613-e1617. doi: 10.1212/WNL.0000000000005425. Epub 2018 Apr 4. Neurology. 2018. PMID: 29618626 Free PMC article.
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