O'Brien PM - Search Results

1

Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 17. Structure-activity relationships of several series of compounds derived from N-chlorosulfonyl isocyanate.

Picard JA, O'Brien PM, Sliskovic DR, Anderson MK, Bousley RF, Hamelehle KL, Krause BR, Stanfield RL. Picard JA, et al. J Med Chem. 1996 Mar 15;39(6):1243-52. doi: 10.1021/jm9509455. J Med Chem. 1996. PMID: 8632431

2

Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo.

O'Brien PM, Sliskovic DR, Blankley CJ, Roth BD, Wilson MW, Hamelehle KL, Krause BR, Stanfield RL. O'Brien PM, et al. J Med Chem. 1994 Jun 10;37(12):1810-22. doi: 10.1021/jm00038a010. J Med Chem. 1994. PMID: 8021920

3

Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives.

O'Brien PM, Sliskovic DR, Picard JA, Lee HT, Purchase CF 2nd, Roth BD, White AD, Anderson M, Mueller SB, Bocan T, Bousley R, Hamelehle KL, Homan R, Lee P, Krause BR, Reindel JF, Stanfield RL, Turluck D. O'Brien PM, et al. J Med Chem. 1996 Jun 7;39(12):2354-66. doi: 10.1021/jm960170f. J Med Chem. 1996. PMID: 8691430

4

alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity.

Sliskovic DR, Picard JA, O'Brien PM, Liao P, Roark WH, Roth BD, Anderson MA, Mueller SB, Bocan TM, Bousley RF, Hamelehle KL, Homan R, Reindel JF, Stanfield RL, Turluck D, Krause BR. Sliskovic DR, et al. J Med Chem. 1998 Feb 26;41(5):682-90. doi: 10.1021/jm970560h. J Med Chem. 1998. PMID: 9513596

5

Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors.

O'Brien PM, Ortwine DF, Pavlovsky AG, Picard JA, Sliskovic DR, Roth BD, Dyer RD, Johnson LL, Man CF, Hallak H. O'Brien PM, et al. J Med Chem. 2000 Jan 27;43(2):156-66. doi: 10.1021/jm9903141. J Med Chem. 2000. PMID: 10649971

6

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.

Roth BD, Bocan TM, Blankley CJ, Chucholowski AW, Creger PL, Creswell MW, Ferguson E, Newton RS, O'Brien P, Picard JA, et al. Roth BD, et al. J Med Chem. 1991 Jan;34(1):463-6. doi: 10.1021/jm00105a071. J Med Chem. 1991. PMID: 1992149 No abstract available.

7

Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation.

Bocan TM, Mazur MJ, Mueller SB, Brown EQ, Sliskovic DR, O'Brien PM, Creswell MW, Lee H, Uhlendorf PD, Roth BD, et al. Bocan TM, et al. Atherosclerosis. 1994 Nov;111(1):127-42. doi: 10.1016/0021-9150(94)90198-8. Atherosclerosis. 1994. PMID: 7840808

8

Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.

Peterson JT, Hallak H, Johnson L, Li H, O'Brien PM, Sliskovic DR, Bocan TM, Coker ML, Etoh T, Spinale FG. Peterson JT, et al. Circulation. 2001 May 8;103(18):2303-9. doi: 10.1161/01.cir.103.18.2303. Circulation. 2001. PMID: 11342481

9

Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

Li JJ, Nahra J, Johnson AR, Bunker A, O'Brien P, Yue WS, Ortwine DF, Man CF, Baragi V, Kilgore K, Dyer RD, Han HK. Li JJ, et al. J Med Chem. 2008 Feb 28;51(4):835-41. doi: 10.1021/jm701274v. Epub 2008 Feb 6. J Med Chem. 2008. PMID: 18251495

10

Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors.

Parker MH, Ortwine DF, O'Brien PM, Lunney EA, Banotai CA, Mueller WT, McConnell P, Brouillette CG. Parker MH, et al. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2427-30. doi: 10.1016/s0960-894x(00)00495-9. Bioorg Med Chem Lett. 2000. PMID: 11078193

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