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Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.
Gerwin BI, Spillare E, Forrester K, Lehman TA, Kispert J, Welsh JA, Pfeifer AM, Lechner JF, Baker SJ, Vogelstein B, et al. Gerwin BI, et al. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2759-63. doi: 10.1073/pnas.89.7.2759. Proc Natl Acad Sci U S A. 1992. PMID: 1557382 Free PMC article.
Mutations and altered expression of p16INK4 in human cancer.
Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH, et al. Okamoto A, et al. Among authors: spillare ea. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11045-9. doi: 10.1073/pnas.91.23.11045. Proc Natl Acad Sci U S A. 1994. PMID: 7972006 Free PMC article.
Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.
Okamoto A, Jiang W, Kim SJ, Spillare EA, Stoner GD, Weinstein IB, Harris CC. Okamoto A, et al. Among authors: spillare ea. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11576-80. doi: 10.1073/pnas.91.24.11576. Proc Natl Acad Sci U S A. 1994. PMID: 7972105 Free PMC article.
p53-mediated apoptosis is attenuated in Werner syndrome cells.
Spillare EA, Robles AI, Wang XW, Shen JC, Yu CE, Schellenberg GD, Harris CC. Spillare EA, et al. Genes Dev. 1999 Jun 1;13(11):1355-60. doi: 10.1101/gad.13.11.1355. Genes Dev. 1999. PMID: 10364153 Free PMC article.
Functional interaction of p53 and BLM DNA helicase in apoptosis.
Wang XW, Tseng A, Ellis NA, Spillare EA, Linke SP, Robles AI, Seker H, Yang Q, Hu P, Beresten S, Bemmels NA, Garfield S, Harris CC. Wang XW, et al. Among authors: spillare ea. J Biol Chem. 2001 Aug 31;276(35):32948-55. doi: 10.1074/jbc.M103298200. Epub 2001 Jun 8. J Biol Chem. 2001. PMID: 11399766 Free article.
p53 Modulates the exonuclease activity of Werner syndrome protein.
Brosh RM Jr, Karmakar P, Sommers JA, Yang Q, Wang XW, Spillare EA, Harris CC, Bohr VA. Brosh RM Jr, et al. Among authors: spillare ea. J Biol Chem. 2001 Sep 14;276(37):35093-102. doi: 10.1074/jbc.M103332200. Epub 2001 Jun 26. J Biol Chem. 2001. PMID: 11427532 Free article.
Redundancy of DNA helicases in p53-mediated apoptosis.
Spillare EA, Wang XW, von Kobbe C, Bohr VA, Hickson ID, Harris CC. Spillare EA, et al. Oncogene. 2006 Mar 30;25(14):2119-23. doi: 10.1038/sj.onc.1209242. Oncogene. 2006. PMID: 16288211 Free PMC article.
26 results