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Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.
Chen P, Cheng PT, Alam M, Beyer BD, Bisacchi GS, Dejneka T, Evans AJ, Greytok JA, Hermsmeier MA, Humphreys WG, Jacobs GA, Kocy O, Lin PF, Lis KA, Marella MA, Ryono DE, Sheaffer AK, Spergel SH, Sun CQ, Tino JA, Vite G, Colonno RJ, Zahler R, Barrish JC. Chen P, et al. Among authors: jacobs ga. J Med Chem. 1996 May 10;39(10):1991-2007. doi: 10.1021/jm950717a. J Med Chem. 1996. PMID: 8642558
Synthesis and antiviral activity of novel isonucleoside analogs.
Tino JA, Clark JM, Field AK, Jacobs GA, Lis KA, Michalik TL, McGeever-Rubin B, Slusarchyk WA, Spergel SH, Sundeen JE, et al. Tino JA, et al. Among authors: jacobs ga. J Med Chem. 1993 Apr 30;36(9):1221-9. doi: 10.1021/jm00061a013. J Med Chem. 1993. PMID: 8387600
Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
Sutton JC, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Slusarchyk WA, Treuner U, Zahler R, Zhao G, Bisacchi GS. Sutton JC, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33. doi: 10.1016/s0960-894x(02)00688-1. Bioorg Med Chem Lett. 2002. PMID: 12372540
Synthesis of potent and highly selective inhibitors of human tryptase.
Slusarchyk WA, Bolton SA, Hartl KS, Huang MH, Jacobs G, Meng W, Ogletree ML, Pi Z, Schumacher WA, Seiler SM, Sutton JC, Treuner U, Zahler R, Zhao G, Bisacchi GS. Slusarchyk WA, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8. doi: 10.1016/s0960-894x(02)00689-3. Bioorg Med Chem Lett. 2002. PMID: 12372541
Ocean convergence and the dispersion of flotsam.
D'Asaro EA, Shcherbina AY, Klymak JM, Molemaker J, Novelli G, Guigand CM, Haza AC, Haus BK, Ryan EH, Jacobs GA, Huntley HS, Laxague NJM, Chen S, Judt F, McWilliams JC, Barkan R, Kirwan AD Jr, Poje AC, Özgökmen TM. D'Asaro EA, et al. Among authors: jacobs ga. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1162-1167. doi: 10.1073/pnas.1718453115. Epub 2018 Jan 16. Proc Natl Acad Sci U S A. 2018. PMID: 29339497 Free PMC article.
63 results