Orth K - Search Results

1

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.

Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM. Duan H, et al. Among authors: orth k. J Biol Chem. 1996 Jul 12;271(28):16720-4. doi: 10.1074/jbc.271.28.16720. J Biol Chem. 1996. PMID: 8663294 Free article.

2

Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases.

Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM. Chinnaiyan AM, et al. Among authors: orth k. J Biol Chem. 1996 Mar 1;271(9):4573-6. doi: 10.1074/jbc.271.9.4573. J Biol Chem. 1996. PMID: 8617712 Free article.

3

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.

Orth K, Chinnaiyan AM, Garg M, Froelich CJ, Dixit VM. Orth K, et al. J Biol Chem. 1996 Jul 12;271(28):16443-6. J Biol Chem. 1996. PMID: 8663580 Free article.

4

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.

Orth K, O'Rourke K, Salvesen GS, Dixit VM. Orth K, et al. J Biol Chem. 1996 Aug 30;271(35):20977-80. doi: 10.1074/jbc.271.35.20977. J Biol Chem. 1996. PMID: 8702858 Free article.

5

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.

Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM. Chinnaiyan AM, et al. Among authors: orth k. Curr Biol. 1996 Jul 1;6(7):897-9. doi: 10.1016/s0960-9822(02)00614-0. Curr Biol. 1996. PMID: 8805307 Free article.

6

New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.

Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W. Froelich CJ, et al. Among authors: orth k. J Biol Chem. 1996 Nov 15;271(46):29073-9. doi: 10.1074/jbc.271.46.29073. J Biol Chem. 1996. PMID: 8910561 Free article.

7

Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis.

Orth K, Dixit VM. Orth K, et al. J Biol Chem. 1997 Apr 4;272(14):8841-4. doi: 10.1074/jbc.272.14.8841. J Biol Chem. 1997. PMID: 9082997 Free article.

8

Target protease specificity of the viral serpin CrmA. Analysis of five caspases.

Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS. Zhou Q, et al. Among authors: orth k. J Biol Chem. 1997 Mar 21;272(12):7797-800. doi: 10.1074/jbc.272.12.7797. J Biol Chem. 1997. PMID: 9065443 Free article.

9

Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates.

D'Amours D, Germain M, Orth K, Dixit VM, Poirier GG. D'Amours D, et al. Among authors: orth k. Radiat Res. 1998 Jul;150(1):3-10. Radiat Res. 1998. PMID: 9650595

10

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

Talanian RV, Yang X, Turbov J, Seth P, Ghayur T, Casiano CA, Orth K, Froelich CJ. Talanian RV, et al. Among authors: orth k. J Exp Med. 1997 Oct 20;186(8):1323-31. doi: 10.1084/jem.186.8.1323. J Exp Med. 1997. PMID: 9334372 Free PMC article.

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