Lewis AD - Search Results

1

The pharmacokinetics, bioavailability and biodistribution in mice of a rationally designed 2-nitroimidazole hypoxia probe SR-4554.

Aboagye EO, Lewis AD, Graham MA, Tracy M, Kelson AB, Ryan KJ, Workman P. Aboagye EO, et al. Among authors: lewis ad. Anticancer Drug Des. 1996 Apr;11(3):231-42. Anticancer Drug Des. 1996. PMID: 8663910

2

Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554).

Aboagye EO, Lewis AD, Tracy M, Workman P. Aboagye EO, et al. Among authors: lewis ad. Biochem Pharmacol. 1997 Dec 1;54(11):1217-24. doi: 10.1016/s0006-2952(97)00344-4. Biochem Pharmacol. 1997. PMID: 9416972 Free article.

3

The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.

Aboagye EO, Maxwell RJ, Horsman MR, Lewis AD, Workman P, Tracy M, Griffiths JR. Aboagye EO, et al. Among authors: lewis ad. Br J Cancer. 1998;77(1):65-70. doi: 10.1038/bjc.1998.10. Br J Cancer. 1998. PMID: 9459147 Free PMC article.

4

The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis.

Aboagye EO, Lewis AD, Johnson A, Workman P, Tracy M, Huxham IM. Aboagye EO, et al. Among authors: lewis ad. Br J Cancer. 1995 Aug;72(2):312-8. doi: 10.1038/bjc.1995.330. Br J Cancer. 1995. PMID: 7640211 Free PMC article.

5

Development and validation of a solid-phase extraction and high-performance liquid chromatographic assay for a novel fluorinated 2-nitroimidazole hypoxia probe (SR-4554) in Balb/c mouse plasma.

Aboagye EO, Graham MA, Lewis AD, Workman P, Kelson AB, Tracy M. Aboagye EO, et al. Among authors: lewis ad. J Chromatogr B Biomed Appl. 1995 Oct 6;672(1):125-32. doi: 10.1016/0378-4347(95)00204-v. J Chromatogr B Biomed Appl. 1995. PMID: 8590924

6

Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.

Aboagye EO, Maxwell RJ, Kelson AB, Tracy M, Lewis AD, Graham MA, Horsman MR, Griffiths JR, Workman P. Aboagye EO, et al. Among authors: lewis ad. Cancer Res. 1997 Aug 1;57(15):3314-8. Cancer Res. 1997. PMID: 9242466

7

Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.

Bailey SM, Wyatt MD, Friedlos F, Hartley JA, Knox RJ, Lewis AD, Workman P. Bailey SM, et al. Among authors: lewis ad. Br J Cancer. 1997;76(12):1596-603. doi: 10.1038/bjc.1997.603. Br J Cancer. 1997. PMID: 9413948 Free PMC article.

8

Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.

Rampling R, Cruickshank G, Lewis AD, Fitzsimmons SA, Workman P. Rampling R, et al. Among authors: lewis ad. Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):427-31. doi: 10.1016/0360-3016(94)90432-4. Int J Radiat Oncol Biol Phys. 1994. PMID: 8005794

9

Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.

Fitzsimmons SA, Lewis AD, Riley RJ, Workman P. Fitzsimmons SA, et al. Among authors: lewis ad. Carcinogenesis. 1994 Aug;15(8):1503-10. doi: 10.1093/carcin/15.8.1503. Carcinogenesis. 1994. PMID: 8055626

10

Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase.

Brunton VG, Steele G, Lewis AD, Workman P. Brunton VG, et al. Among authors: lewis ad. Cancer Chemother Pharmacol. 1998;41(5):417-22. doi: 10.1007/s002800050760. Cancer Chemother Pharmacol. 1998. PMID: 9523739

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