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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Jirousek MR, Gillig JR, Gonzalez CM, Heath WF, McDonald JH 3rd, Neel DA, Rito CJ, Singh U, Stramm LE, Melikian-Badalian A, Baevsky M, Ballas LM, Hall SE, Winneroski LL, Faul MM. Jirousek MR, et al. Among authors: singh u. J Med Chem. 1996 Jul 5;39(14):2664-71. doi: 10.1021/jm950588y. J Med Chem. 1996. PMID: 8709095
Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats.
Barawkar DA, Meru A, Bandyopadhyay A, Banerjee A, Deshpande AM, Athare C, Koduru C, Khose G, Gundu J, Mahajan K, Patil P, Kandalkar SR, Niranjan S, Bhosale S, De S, Mukhopadhyay S, Chaudhary S, Koul S, Singh U, Chugh A, Palle VP, Mookhtiar KA, Vacca J, Chakravarty PK, Nargund RP, Wright SD, Roy S, Graziano MP, Singh SB, Cully D, Cai TQ. Barawkar DA, et al. Among authors: singh sb, singh u. ACS Med Chem Lett. 2011 Oct 7;2(12):919-23. doi: 10.1021/ml2001938. eCollection 2011 Dec 8. ACS Med Chem Lett. 2011. PMID: 24900281 Free PMC article.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase.
Barawkar DA, Bandyopadhyay A, Deshpande A, Koul S, Kandalkar S, Patil P, Khose G, Vyas S, Mone M, Bhosale S, Singh U, De S, Meru A, Gundu J, Chugh A, Palle VP, Mookhtiar KA, Vacca JP, Chakravarty PK, Nargund RP, Wright SD, Roy S, Graziano MP, Cully D, Cai TQ, Singh SB. Barawkar DA, et al. Among authors: singh sb, singh u. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4341-7. doi: 10.1016/j.bmcl.2012.05.020. Epub 2012 May 11. Bioorg Med Chem Lett. 2012. PMID: 22658862
Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation.
Koul S, Kurhade S, Bhosale S, Naik K, Salunkhe V, Ravula S, Punde P, Velayutham R, Tiwari A, Ahl D, Malkapuram S, Mudagala V, Raje A, Umrani D, Tambe S, Patil P, Singh U, Bhuniya D, Hariharan N, Mookhtiar K. Koul S, et al. Among authors: singh u. Bioorg Med Chem Lett. 2022 Apr 15;62:128632. doi: 10.1016/j.bmcl.2022.128632. Epub 2022 Feb 18. Bioorg Med Chem Lett. 2022. PMID: 35189320
2024 Update of the RECOVER-Adult Long COVID Research Index.
Geng LN, Erlandson KM, Hornig M, Letts R, Selvaggi C, Ashktorab H, Atieh O, Bartram L, Brim H, Brosnahan SB, Brown J, Castro M, Charney A, Chen P, Deeks SG, Erdmann N, Flaherman VJ, Ghamloush MA, Goepfert P, Goldman JD, Han JE, Hess R, Hirshberg E, Hoover SE, Katz SD, Kelly JD, Klein JD, Krishnan JA, Lee-Iannotti J, Levitan EB, Marconi VC, Metz TD, Modes ME, Nikolich JŽ, Novak RM, Ofotokun I, Okumura MJ, Parthasarathy S, Patterson TF, Peluso MJ, Poppas A, Quintero Cardona O, Scott J, Shellito J, Sherif ZA, Singer NG, Taylor BS, Thaweethai T, Verduzco-Gutierrez M, Wisnivesky J, McComsey GA, Horwitz LI, Foulkes AS; RECOVER Consortium. Geng LN, et al. JAMA. 2024 Dec 18. doi: 10.1001/jama.2024.24184. Online ahead of print. JAMA. 2024. PMID: 39693079
Nidogen 2 Overexpression Promotes Hepatosteatosis and Atherosclerosis.
Kathuria I, Prasad A, Sharma BK, Aithabathula RV, Ofosu-Boateng M, Gyamfi MA, Jiang J, Park F, Singh UP, Singla B. Kathuria I, et al. Among authors: singh up. Int J Mol Sci. 2024 Nov 28;25(23):12782. doi: 10.3390/ijms252312782. Int J Mol Sci. 2024. PMID: 39684493 Free PMC article.
Smooth muscle cell-specific CD47 deletion suppresses atherosclerosis.
Pervaiz N, Mehmood R, Aithabathula RV, Kathuria I, Ahn W, Le BT, Kim KS, Singh UP, Csanyi G, Singla B. Pervaiz N, et al. Among authors: singh up. Life Sci. 2024 Dec 13;361:123315. doi: 10.1016/j.lfs.2024.123315. Online ahead of print. Life Sci. 2024. PMID: 39675550
2,222 results