Bridger GJ - Search Results

1

The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding.

De Vreese K, Reymen D, Griffin P, Steinkasserer A, Werner G, Bridger GJ, Esté J, James W, Henson GW, Desmyter J, Anné J, De Clercq I. De Vreese K, et al. Among authors: bridger gj. Antiviral Res. 1996 Mar;29(2-3):209-19. doi: 10.1016/0166-3542(95)00837-3. Antiviral Res. 1996. PMID: 8739600

2

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.

Esté JA, De Vreese K, Witvrouw M, Schmit JC, Vandamme AM, Anné J, Desmyter J, Henson GW, Bridger G, De Clercq E. Esté JA, et al. Antiviral Res. 1996 Mar;29(2-3):297-307. doi: 10.1016/0166-3542(95)00936-1. Antiviral Res. 1996. PMID: 8739608

3

Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

Hatse S, Princen K, Gerlach LO, Bridger G, Henson G, De Clercq E, Schwartz TW, Schols D. Hatse S, et al. Mol Pharmacol. 2001 Jul;60(1):164-73. doi: 10.1124/mol.60.1.164. Mol Pharmacol. 2001. PMID: 11408611

4

Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4.

Esté JA, Cabrera C, Blanco J, Gutierrez A, Bridger G, Henson G, Clotet B, Schols D, De Clercq E. Esté JA, et al. J Virol. 1999 Jul;73(7):5577-85. doi: 10.1128/JVI.73.7.5577-5585.1999. J Virol. 1999. PMID: 10364306 Free PMC article.

5

The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis.

Blanco J, Barretina J, Henson G, Bridger G, De Clercq E, Clotet B, Esté JA. Blanco J, et al. Antimicrob Agents Chemother. 2000 Jan;44(1):51-6. doi: 10.1128/AAC.44.1.51-56.2000. Antimicrob Agents Chemother. 2000. PMID: 10602722 Free PMC article.

6

Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors.

Joao HC, De Vreese K, Pauwels R, De Clercq E, Henson GW, Bridger GJ. Joao HC, et al. Among authors: bridger gj. J Med Chem. 1995 Sep 15;38(19):3865-73. doi: 10.1021/jm00019a017. J Med Chem. 1995. PMID: 7562918

7

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams.

Bridger GJ, Skerlj RT, Padmanabhan S, Martellucci SA, Henson GW, Abrams MJ, Joao HC, Witvrouw M, De Vreese K, Pauwels R, De Clercq E. Bridger GJ, et al. J Med Chem. 1996 Jan 5;39(1):109-19. doi: 10.1021/jm950584t. J Med Chem. 1996. PMID: 8568797

8

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.

Bridger GJ, Skerlj RT, Thornton D, Padmanabhan S, Martellucci SA, Henson GW, Abrams MJ, Yamamoto N, De Vreese K, Pauwels R, et al. Bridger GJ, et al. J Med Chem. 1995 Jan 20;38(2):366-78. doi: 10.1021/jm00002a019. J Med Chem. 1995. PMID: 7830280

9

AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

Matthys P, Hatse S, Vermeire K, Wuyts A, Bridger G, Henson GW, De Clercq E, Billiau A, Schols D. Matthys P, et al. J Immunol. 2001 Oct 15;167(8):4686-92. doi: 10.4049/jimmunol.167.8.4686. J Immunol. 2001. PMID: 11591799

10

Bicyclams, selective antagonists of the human chemokine receptor CXCR4, potently inhibit feline immunodeficiency virus replication.

Egberink HF, De Clercq E, Van Vliet AL, Balzarini J, Bridger GJ, Henson G, Horzinek MC, Schols D. Egberink HF, et al. Among authors: bridger gj. J Virol. 1999 Aug;73(8):6346-52. doi: 10.1128/JVI.73.8.6346-6352.1999. J Virol. 1999. PMID: 10400726 Free PMC article.

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