Faraj A - Search Results

1

Quantitation of 3'-amino-3'-deoxythymidine (AMT), a toxic catabolite of 3'-azido-3'-deoxythymidine (AZT), by competitive ELISA.

Ferrua B, Chakboub H, Roptin C, Garraffo R, Faraj A, Grassi J, Guedj R, Sommadossi JP. Ferrua B, et al. Among authors: faraj a. J Immunoassay. 1996 May;17(2):175-93. doi: 10.1080/01971529608005787. J Immunoassay. 1996. PMID: 8744286

2

Inhibition of mammalian DNA polymerase-associated 3' to 5' exonuclease activity by 5'-monophosphates of 3'-azido-3'-deoxythymidine and 3'-amino-3'-deoxythymidine.

Bridges EG, Faraj A, Sommadossi JP. Bridges EG, et al. Among authors: faraj a. Biochem Pharmacol. 1993 Apr 22;45(8):1571-6. doi: 10.1016/0006-2952(93)90296-9. Biochem Pharmacol. 1993. PMID: 8387298

3

Effects of 2',3'-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis.

Faraj A, Fowler DA, Bridges EG, Sommadossi JP. Faraj A, et al. Antimicrob Agents Chemother. 1994 May;38(5):924-30. doi: 10.1128/AAC.38.5.924. Antimicrob Agents Chemother. 1994. PMID: 7520683 Free PMC article.

4

Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.

Faraj A, Schinazi RF, Xie MY, Gosselin G, Perigaud C, Imbach JL, Sommadossi JP. Faraj A, et al. Antiviral Res. 1996 Mar;29(2-3):261-7. doi: 10.1016/0166-3542(95)00905-1. Antiviral Res. 1996. PMID: 8739604

5

Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.

Pierra C, Gosselin G, Sommadossi JP, Faraj A, De Clercq E, Balzarini J, Imbach JL. Pierra C, et al. Among authors: faraj a. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):643-4. doi: 10.1080/15257779908041526. Nucleosides Nucleotides. 1999. PMID: 10432657

6

Effects of beta-L-3'-azido-3'-deoxythymidine 5'-triphosphate on host and viral DNA polymerases.

Faraj A, El Alaoui AM, Gosselin G, Imbach JL, Morrow C, Sommadossi JP. Faraj A, et al. Antiviral Res. 2000 Aug;47(2):97-102. doi: 10.1016/s0166-3542(00)00095-4. Antiviral Res. 2000. PMID: 10996397

However, the inhibitory effect of L-AZTTP towards HIV-1 RT was very modest (266-fold less potent) when compared to its isomer beta-D-AZT 5'-triphosphate (D-AZTTP) which exhibits a K(i) value of 0.0075 microM and this finding was further confirmed by DNA chain termination a …

However, the inhibitory effect of L-AZTTP towards HIV-1 RT was very modest (266-fold less potent) when compared to its isomer beta-D-AZT 5'- …

7

Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides.

Pierra C, Imbach JL, De Clercq E, Balzarini J, Van Aerschot A, Herdewijn P, Faraj A, Loi AG, Sommadossi JP, Gosselin G. Pierra C, et al. Among authors: faraj a. Antiviral Res. 2000 Mar;45(3):169-83. doi: 10.1016/s0166-3542(00)00069-3. Antiviral Res. 2000. PMID: 10771081

8

Effect of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil on mitochondrial functions in HepG2 cells.

Cui L, Faraj A, Sommadossi JP. Cui L, et al. Among authors: faraj a. Antiviral Res. 1999 Oct;43(3):201-7. doi: 10.1016/s0166-3542(99)00050-9. Antiviral Res. 1999. PMID: 10551377

9

NDP kinase reactivity towards 3TC nucleotides.

Kreimeyer A, Schneider B, Sarfati R, Faraj A, Sommadossi JP, Veron M, Deville-Bonne D. Kreimeyer A, et al. Among authors: faraj a. Antiviral Res. 2001 May;50(2):147-56. doi: 10.1016/s0166-3542(01)00139-5. Antiviral Res. 2001. PMID: 11369435

10

Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine.

Griffon JF, Mathé C, Faraj A, Aubertin AM, De Clercq E, Balzarini J, Sommadossi JP, Gosselin G. Griffon JF, et al. Among authors: faraj a. Eur J Med Chem. 2001 May;36(5):447-60. doi: 10.1016/s0223-5234(01)01238-7. Eur J Med Chem. 2001. PMID: 11451533

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