Light Y - Search Results

1

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.

Marais R, Spooner RA, Light Y, Martin J, Springer CJ. Marais R, et al. Among authors: light y. Cancer Res. 1996 Oct 15;56(20):4735-42. Cancer Res. 1996. PMID: 8840992

2

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy.

Marais R, Spooner RA, Stribbling SM, Light Y, Martin J, Springer CJ. Marais R, et al. Among authors: light y. Nat Biotechnol. 1997 Dec;15(13):1373-7. doi: 10.1038/nbt1297-1373. Nat Biotechnol. 1997. PMID: 9415889

3

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin.

da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R. da Rocha Dias S, et al. Among authors: light y. Cancer Res. 2005 Dec 1;65(23):10686-91. doi: 10.1158/0008-5472.CAN-05-2632. Cancer Res. 2005. PMID: 16322212

4

Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.

Dumaz N, Light Y, Marais R. Dumaz N, et al. Among authors: light y. Mol Cell Biol. 2002 Jun;22(11):3717-28. doi: 10.1128/MCB.22.11.3717-3728.2002. Mol Cell Biol. 2002. PMID: 11997508 Free PMC article.

5

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

Marais R, Light Y, Paterson HF, Marshall CJ. Marais R, et al. Among authors: light y. EMBO J. 1995 Jul 3;14(13):3136-45. doi: 10.1002/j.1460-2075.1995.tb07316.x. EMBO J. 1995. PMID: 7542586 Free PMC article.

6

Expression of kinase suppressor of Ras in the normal adult and embryonic mouse.

Giblett SM, Lloyd DJ, Light Y, Marais R, Pritchard CA. Giblett SM, et al. Among authors: light y. Cell Growth Differ. 2002 Jul;13(7):307-13. Cell Growth Differ. 2002. PMID: 12133899

7

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases.

Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ. Marais R, et al. Among authors: light y. J Biol Chem. 1997 Feb 14;272(7):4378-83. doi: 10.1074/jbc.272.7.4378. J Biol Chem. 1997. PMID: 9020159 Free article.

This synergy arises because Ras-GTP translocates Raf-1 to the plasma membrane where it becomes phosphorylated on tyrosine residues 340 and 341 by membrane-bound tyrosine kinases (Marais, R., Light, Y., Paterson, H. F., and Marshall, C. J. (1995) EMBO J. 14, 3136-314 …

This synergy arises because Ras-GTP translocates Raf-1 to the plasma membrane where it becomes phosphorylated on tyrosine residues 340 and 3 …

8

Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.

Marais R, Light Y, Mason C, Paterson H, Olson MF, Marshall CJ. Marais R, et al. Among authors: light y. Science. 1998 Apr 3;280(5360):109-12. doi: 10.1126/science.280.5360.109. Science. 1998. PMID: 9525855

9

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity.

Light Y, Paterson H, Marais R. Light Y, et al. Mol Cell Biol. 2002 Jul;22(14):4984-96. doi: 10.1128/MCB.22.14.4984-4996.2002. Mol Cell Biol. 2002. PMID: 12077328 Free PMC article.

10

Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression.

John S, Marais R, Child R, Light Y, Leonard WJ. John S, et al. Among authors: light y. J Exp Med. 1996 Mar 1;183(3):743-50. doi: 10.1084/jem.183.3.743. J Exp Med. 1996. PMID: 8642278 Free PMC article.

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