Macmillan LB - Search Results

1

Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals.

Wang R, Macmillan LB, Fremeau RT Jr, Magnuson MA, Lindner J, Limbird LE. Wang R, et al. Among authors: macmillan lb. Neuroscience. 1996 Sep;74(1):199-218. doi: 10.1016/0306-4522(96)00116-9. Neuroscience. 1996. PMID: 8843087

2

Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE. MacMillan LB, et al. Science. 1996 Aug 9;273(5276):801-3. doi: 10.1126/science.273.5276.801. Science. 1996. PMID: 8670421

3

Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings.

MacMillan LB, Lakhlani P, Lovinger D, Limbird LE. MacMillan LB, et al. Recent Prog Horm Res. 1998;53:25-42. Recent Prog Horm Res. 1998. PMID: 9769701 Review.

4

Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.

Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE. Tan CM, et al. Among authors: macmillan lb. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12471-6. doi: 10.1073/pnas.122368499. Epub 2002 Aug 30. Proc Natl Acad Sci U S A. 2002. PMID: 12205290 Free PMC article.

5

Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo.

Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE. Lakhlani PP, et al. Among authors: macmillan lb. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9950-5. doi: 10.1073/pnas.94.18.9950. Proc Natl Acad Sci U S A. 1997. PMID: 9275232 Free PMC article.

6

In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes.

MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. MacMillan LB, et al. Adv Pharmacol. 1998;42:493-6. doi: 10.1016/s1054-3589(08)60796-6. Adv Pharmacol. 1998. PMID: 9327947 No abstract available.

7

A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine.

Janumpalli S, Butler LS, MacMillan LB, Limbird LE, McNamara JO. Janumpalli S, et al. Among authors: macmillan lb. J Neurosci. 1998 Mar 15;18(6):2004-8. doi: 10.1523/JNEUROSCI.18-06-02004.1998. J Neurosci. 1998. PMID: 9482787 Free PMC article.

8

The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy.

Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL. Stone LS, et al. Among authors: macmillan lb. J Neurosci. 1997 Sep 15;17(18):7157-65. doi: 10.1523/JNEUROSCI.17-18-07157.1997. J Neurosci. 1997. PMID: 9278550 Free PMC article.

9

Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice.

Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Altman JD, et al. Mol Pharmacol. 1999 Jul;56(1):154-61. doi: 10.1124/mol.56.1.154. Mol Pharmacol. 1999. PMID: 10385696

10

Alpha-adrenoceptors and vascular regulation: molecular, pharmacologic and clinical correlates.

Piascik MT, Soltis EE, Piascik MM, Macmillan LB. Piascik MT, et al. Among authors: macmillan lb. Pharmacol Ther. 1996;72(3):215-41. doi: 10.1016/s0163-7258(96)00117-9. Pharmacol Ther. 1996. PMID: 9364576 Review.

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