Eckman C - Search Results

1

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.

Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S. Duff K, et al. Among authors: eckman c. Nature. 1996 Oct 24;383(6602):710-3. doi: 10.1038/383710a0. Nature. 1996. PMID: 8878479

2

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Scheuner D, et al. Among authors: eckman c. Nat Med. 1996 Aug;2(8):864-70. doi: 10.1038/nm0896-864. Nat Med. 1996. PMID: 8705854

3

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.

Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K. Holcomb L, et al. Among authors: eckman c. Nat Med. 1998 Jan;4(1):97-100. doi: 10.1038/nm0198-097. Nat Med. 1998. PMID: 9427614

4

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

Refolo LM, Eckman C, Prada CM, Yager D, Sambamurti K, Mehta N, Hardy J, Younkin SG. Refolo LM, et al. Among authors: eckman c. J Neurochem. 1999 Dec;73(6):2383-8. doi: 10.1046/j.1471-4159.1999.0732383.x. J Neurochem. 1999. PMID: 10582597 Free article.

5

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).

Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Prada CM, Younkin SG, Hutton M, Hardy J. Eckman CB, et al. Hum Mol Genet. 1997 Nov;6(12):2087-9. doi: 10.1093/hmg/6.12.2087. Hum Mol Genet. 1997. PMID: 9328472

6

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.

De Jonghe C, Zehr C, Yager D, Prada CM, Younkin S, Hendriks L, Van Broeckhoven C, Eckman CB. De Jonghe C, et al. Among authors: eckman cb. Neurobiol Dis. 1998 Oct;5(4):281-6. doi: 10.1006/nbdi.1998.0202. Neurobiol Dis. 1998. PMID: 9848098

7

Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein.

Sambamurti K, Sevlever D, Koothan T, Refolo LM, Pinnix I, Gandhi S, Onstead L, Younkin L, Prada CM, Yager D, Ohyagi Y, Eckman CB, Rosenberry TL, Younkin SG. Sambamurti K, et al. Among authors: eckman cb. J Biol Chem. 1999 Sep 17;274(38):26810-4. doi: 10.1074/jbc.274.38.26810. J Biol Chem. 1999. PMID: 10480887 Free article.

8

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.

Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG. Harigaya Y, et al. Among authors: eckman cb. Biochem Biophys Res Commun. 2000 Sep 24;276(2):422-7. doi: 10.1006/bbrc.2000.3490. Biochem Biophys Res Commun. 2000. PMID: 11027491

9

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.

Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, Eckman CB. Haugabook SJ, et al. Among authors: eckman ea, eckman cb. FASEB J. 2001 Jan;15(1):16-18. doi: 10.1096/fj.00-0528fje. Epub 2000 Nov 9. FASEB J. 2001. PMID: 11099491

10

Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.

Mehta ND, Refolo LM, Eckman C, Sanders S, Yager D, Perez-Tur J, Younkin S, Duff K, Hardy J, Hutton M. Mehta ND, et al. Among authors: eckman c. Ann Neurol. 1998 Feb;43(2):256-8. doi: 10.1002/ana.410430217. Ann Neurol. 1998. PMID: 9485068

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