Hardy J - Search Results

1

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.

Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S. Duff K, et al. Among authors: hardy j. Nature. 1996 Oct 24;383(6602):710-3. doi: 10.1038/383710a0. Nature. 1996. PMID: 8878479

2

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Scheuner D, et al. Among authors: hardy j. Nat Med. 1996 Aug;2(8):864-70. doi: 10.1038/nm0896-864. Nat Med. 1996. PMID: 8705854

3

A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease.

Perez-Tur J, Croxton R, Wright K, Phillips H, Zehr C, Crook R, Hutton M, Hardy J, Karran E, Roberts GW, Lancaster S, Haltia T. Perez-Tur J, et al. Among authors: hardy j. Neurodegeneration. 1996 Sep;5(3):207-12. doi: 10.1006/neur.1996.0028. Neurodegeneration. 1996. PMID: 8910898

4

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.

Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K. Holcomb L, et al. Among authors: hardy j. Nat Med. 1998 Jan;4(1):97-100. doi: 10.1038/nm0198-097. Nat Med. 1998. PMID: 9427614

5

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M. Hardy J, et al. Among authors: hardy kg. Nat Neurosci. 1998 Sep;1(5):355-8. doi: 10.1038/1565. Nat Neurosci. 1998. PMID: 10196523 Review.

6

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

Refolo LM, Eckman C, Prada CM, Yager D, Sambamurti K, Mehta N, Hardy J, Younkin SG. Refolo LM, et al. Among authors: hardy j. J Neurochem. 1999 Dec;73(6):2383-8. doi: 10.1046/j.1471-4159.1999.0732383.x. J Neurochem. 1999. PMID: 10582597 Free article.

7

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. Morgan D, et al. Among authors: hardy j. Nature. 2000 Dec 21-28;408(6815):982-5. doi: 10.1038/35050116. Nature. 2000. PMID: 11140686

8

A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.

Mullan M, Houlden H, Windelspecht M, Fidani L, Lombardi C, Diaz P, Rossor M, Crook R, Hardy J, Duff K, et al. Mullan M, et al. Among authors: hardy j. Nat Genet. 1992 Dec;2(4):340-2. doi: 10.1038/ng1292-340. Nat Genet. 1992. PMID: 1303291

9

Alzheimer's disease. Mouse model made.

Duff K, Hardy J. Duff K, et al. Among authors: hardy j. Nature. 1995 Feb 9;373(6514):476-7. doi: 10.1038/373476a0. Nature. 1995. PMID: 7845455 No abstract available.

10

Heterogeneity in Alzheimer's disease.

Hardy J, Duff K. Hardy J, et al. Ann Med. 1993 Oct;25(5):437-40. doi: 10.3109/07853899309147308. Ann Med. 1993. PMID: 8251141 Free article. Review.

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